Adding Measures of Kidney Function Helps Predict CVD Risk
TUESDAY, March 9, 2021 -- Adding measures of kidney function on top of the atherosclerotic CVD (ASCVD) risk score calculated with traditional factors improves prediction of future cardiovascular disease (CVD) risk, according to a study published online March 4 in the Journal of the American Society of Nephrology.
Yu Xu, M.D., Ph.D., from the Shanghai Jiaotong University School of Medicine, and colleagues studied 115,366 participants in the China Cardiometabolic Disease and Cancer Cohort study to assess CVD risks based on albumin-to-creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR; individually, together, and in combination using the Kidney Disease: Improving Global Outcomes [KDIGO] risk categories). Participants were aged 40 years and older and were examined prospectively for major CVD events.
The researchers identified 2,866 major CVD events during 415,111 person-years of follow-up. Across the KDIGO risk categories in ASCVD risk strata, incidence rates and multivariable-adjusted hazard ratios of CVD events increased significantly. After adding eGFR and log(ACR) to a model including the ASCVD risk score, increases in the C statistic for CVD risk prediction were 0.0116 and 0.0254 in the overall study population and in participants with diabetes, respectively. Significantly improved reclassification of CVD risks was seen with the addition of eGFR and log(ACR) to a model with the ASCVD score (net reclassification improvements, 4.78 percent).
"Consideration of nontraditional CVD risk factors such as eGFR and urinary ACR could further stratify future CVD risks on top of the ASCVD risk score calculated by traditional CVD risk factors," the authors write.
One author disclosed financial ties to the pharmaceutical industry.
© 2021 HealthDay. All rights reserved.
Posted: March 2021
Read this next
TUESDAY, April 20, 2021 -- For U.S. collegiate athletes, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a low prevalence of cardiac...
MONDAY, April 19, 2021 -- Greater intake of red and processed meat is associated with worse imaging measures of cardiovascular health, including adverse ventricular remodeling,...
FRIDAY, April 16, 2021 -- The number of physicians in preventive medicine is unlikely to match the population needs in the United States, according to a study published in the...
More News Resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our Newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.