Skip to Content

AACR: Personalized Vaccine for Cancer Tolerated, Feasible

MONDAY, April 12, 2021 -- A personalized vaccine can be synthesized and is feasible for administration to patients with cancer, according to a study presented during Week 1 of the annual meeting of the American Association for Cancer Research, held virtually from April 10 to 15.

Thomas Urban Marron, M.D., Ph.D., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues developed a personalized genomic vaccine (PGV-001) in patients who had undergone curative-intent surgery or autologous stem cell transplant and for whom there was a >30 percent chance for recurrence. Candidate neoantigens were identified following sequencing of tumor and germline DNA and RNA and use of the OpenVax custom computation pipeline.

The researchers found that the OpenVax pipeline identified an average of 67.1 neoantigens/patient within 15 patients enrolled; only two patients did not have an adequate number of neoantigens identified to synthesize 10 peptides. Thirteen of the patients (10 with solid tumors and three with multiple myeloma) received PGV-001; 11 received all 10 doses. The vaccine was well tolerated; in 31 percent of patients, there were grade 1 injection site reactions. One patient was lost to follow-up; the median progression-free survival was 618 days from the time of surgery or transplant. Four patients remained without evidence of disease with a mean follow-up of 925 days; four are receiving subsequent lines of therapy; and four have died (two with documented recurrence).

"Our results demonstrate that the OpenVax pipeline is a viable approach to generate a safe, personalized cancer vaccine, which could potentially be used to treat a range of tumor types," Marron said in a statement.

Two authors disclosed financial ties to the biopharmaceutical industry.

Press Release

More Information

© 2021 HealthDay. All rights reserved.

Read this next

After Setbacks, Sanofi/GSK COVID-19 Vaccine Performs Well in Early Trial

TUESDAY, May 18, 2021 -- Sanofi and GlaxoSmithKline announced Monday that their COVID-19 vaccine candidate produced powerful responses in a preliminary trial that followed an...

ACC: Only Half of Cardiovascular Disease Patients Receive Flu Vaccine

TUESDAY, May 18, 2021 -- Only half of the U.S. population with cardiovascular disease report being up to date on influenza vaccination, according to a study presented at the...

CDC Director Says New Mask Guidance Is Based on Science

MONDAY, May 17, 2021 -- The decision to ease mask rules for fully vaccinated Americans is based on science and not political pressure, the director of the U.S. Centers for Disease...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.