Generic Name: piperacillin and tazobactam (PI per a SIL in and TAZ oh BAK tam)
Brand Name: Zosyn
Medically reviewed on September 6, 2017
What is piperacillin and tazobactam?
Piperacillin and tazobactam are penicillin antibiotics that fight bacteria in the body.
Piperacillin and tazobactam is a combination medicine used to treat many different infections caused by bacteria, such as urinary tract infections, bone and joint infections, severe vaginal infections, stomach infections, skin infections, and pneumonia.
This medication is sometimes given together with other antibiotics.
Piperacillin and tazobactam may also be used for purposes not listed in this medication guide.
You should not use this medicine if you have ever had an allergic reaction to certain antibiotics (especially a penicillin or cephalosporin antibiotic).
Before taking this medicine
You should not use this medicine if you are allergic to:
To make sure piperacillin and tazobactam is safe for you, tell your doctor if you have ever had:
kidney disease (or if you are on dialysis);
a bleeding or blood clotting disorder;
an electrolyte imbalance such as low levels of potassium in your blood;
any type of allergy; or
if you are on a low-salt diet.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Piperacillin and tazobactam can pass into breast milk, but effects on the nursing baby are not known. Tell your doctor if you are breast-feeding.
How should I use piperacillin and tazobactam?
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Piperacillin and tazobactam is injected into a vein through an IV. You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.
Piperacillin and tazobactam is a powder medicine that must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.
Prepare your dose only when you are ready to give an injection. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.
Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Piperacillin and tazobactam will not treat a viral infection such as the common cold or flu.
While using piperacillin and tazobactam, you may need frequent blood tests.
This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using piperacillin and tazobactam.
Each single-use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.
Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.
Store the unmixed powder medicine and the liquid diluent at cool room temperature, away from moisture and heat. Do not freeze the vial.
Medicine mixed in an IV bag must be used within 24 hours if you keep it at room temperature.
Medicine mixed in a syringe can be stored in a refrigerator for up to 48 hours. Mixed medication in an IV bag can also be stored in the refrigerator for up to 7 days. Do not freeze. Throw away any unused mixture that has not been used within these times.
Mixed medicine in an infusion pump must be used within 12 hours if you keep it at room temperature.
If your medicine is frozen when you receive it, store the medicine container in a freezer until you are ready to prepare your dose.
You may thaw frozen medicine either in a refrigerator or at room temperature. Do not heat the medicine under hot water or in a microwave.
What happens if I miss a dose?
Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using piperacillin and tazobactam?
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.
Piperacillin and tazobactam side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
severe stomach pain, diarrhea that is watery or bloody;
a seizure (convulsions);
low white blood cell counts--fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing;
signs of inflammation in your body--swollen glands, flu symptoms, easy bruising or bleeding, severe tingling or numbness, muscle weakness, upper stomach pain, jaundice (yellowing of the skin or eyes), chest pain, new or worsening cough with fever, trouble breathing; or
severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect piperacillin and tazobactam?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Other drugs may interact with piperacillin and tazobactam, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 6.01.
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- Drug class: beta-lactamase inhibitors