Generic Name: pazopanib (paz OH pa nib)
Brand Name: Votrient
Medically reviewed: August 3, 2017
What is pazopanib?
Pazopanib is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
Pazopanib is also used to treat soft tissue sarcoma (a tumor that can develop in or around muscles, tendons, joints, organs, or blood vessels). Pazopanib is usually given after other cancer medications have been tried without successful treatment of soft tissue sarcoma.
Pazopanib may also be used for purposes not listed in this medication guide.
You should not use this medicine if you have severe liver disease.
Pazopanib can cause severe or life-threatening liver problems. You will need frequent blood tests to check your liver function.
Before taking this medicine
You should not use pazopanib if you are allergic to it, or if you have severe liver disease.
To make sure pazopanib is safe for you, tell your doctor if you have ever had:
heart disease, heart rhythm disorder, long QT syndrome;
a blood clot or stroke;
a thyroid disorder;
headaches, seizures, or vision problems;
a perforation (a hole or tear) in your stomach or intestines;
a fistula (an abnormal passageway) within your stomach or intestines;
stomach or intestinal bleeding within the past 6 months; or
a surgery within the past 7 days.
Do not use pazopanib if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 2 weeks after your last dose.
You may need to have a negative pregnancy test before starting this treatment.
It is not known whether pazopanib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using pazopanib, and for at least 2 weeks after your last dose.
How should I take pazopanib?
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Take pazopanib on an empty stomach, at least 1 hour before or 2 hours after a meal.
Do not crush a pazopanib tablet. Swallow the pill whole. Crushing the pill may cause your body to absorb too much of the drug at one time.
Pazopanib can cause severe or life-threatening liver problems. While using pazopanib, you may need frequent blood or urine tests. Your liver function and blood pressure will also need to be checked often. Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).
If you need surgery, tell the surgeon ahead of time that you are using pazopanib. You may need to stop using the medicine for at least 7 days before your surgery.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 12 hours away. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking pazopanib?
Ask your doctor before using an antacid, and use only the type your doctor recommends. Do not take an antacid within several hours before or after you have taken your pazopanib dose. Avoid taking stomach acid reducers (Axid, Nexium, Pepcid, Prevacid, Prilosec, Protonix, Tagamet, Zantac, Zegerid) while taking pazopanib.
This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Pazopanib side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using pazopanib and call your doctor at once if you have:
unusual bleeding or bruising;
slow healing of a wound or surgical incision, or any wound that will not heal;
sudden chest pain or discomfort, wheezing, dry cough;
headache, confusion, change in mental status, vision loss, seizure (convulsions);
signs of a stroke or blood clot--sudden numbness or weakness, severe headache, slurred speech, vision problems, chest pain, sudden shortness of breath, pain or cold feeling in an arm or leg;
heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
increased blood pressure--severe headache, blurred vision, pounding in your neck or ears, anxiety.
Liver problems may be more likely in adults older than 65.
Common side effects may include:
nausea, vomiting, diarrhea, stomach pain;
loss of appetite, weight loss;
tumor pain, bone pain, muscle pain;
headache, feeling tired;
changes in hair color; or
changes in your sense of taste.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect pazopanib?
Tell your doctor about all your current medicines and any you start or stop using, especially:
heart rhythm medication;
HIV or AIDS medications; or
stomach acid reducers such as Nexium, Prilosec, Tagamet, and others.
This list is not complete. Other drugs may interact with pazopanib, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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