Generic Name: sofosbuvir, velpatasvir, and voxilaprevir (soe FOS bue vir, vel PAT as vir, and VOX i LA pre vir)
Brand Name: Vosevi
What is sofosbuvir, velpatasvir, and voxilaprevir?
Sofosbuvir, velpatasvir, and voxilaprevir are antiviral medications that prevent hepatitis C virus (HCV) from multiplying in your body.
Sofosbuvir, velpatasvir, and voxilaprevir is a combination medicine used to treat chronic hepatitis C in adults with HCV genotype 1, 2, 3, 4, 5, or 6.
This medicine is usually given after other antiviral medicines have been tried without success.
Sofosbuvir, velpatasvir, and voxilaprevir may also be used for purposes not listed in this medication guide.
If you have ever had hepatitis B, this medicine can cause the condition to come back or get worse. You will need frequent blood tests to check your liver function.
Before taking this medicine
You should not use this medicine if you also use rifampin, or if you are allergic to sofosbuvir, velpatasvir, or voxilaprevir.
To make sure this medicine is safe for you, tell your doctor if you have ever had:
liver problems other than hepatitis;
kidney disease (or if you are on dialysis); or
It is not known whether sofosbuvir, velpatasvir, and voxilaprevir will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether sofosbuvir, velpatasvir, and voxilaprevir passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.
How should I take sofosbuvir, velpatasvir, and voxilaprevir?
This medicine is usually taken once per day for 12 weeks. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Take this medicine with food, at the same time each day.
You will need frequent blood tests to check your liver function.
Hepatitis C is often treated with a combination of drugs. Use all medications as directed by your doctor. Read all patient information, medication guides, and instruction sheets provided to you. Do not change your doses or medication schedule without your doctor's advice. Every person with chronic hepatitis C should remain under the care of a doctor.
You should not stop using this medicine suddenly. Stopping suddenly could make your condition harder to treat with hepatitis C antiviral medicine.
If you have ever had hepatitis B, this medicine can cause the condition to come back or get worse. You will need liver function tests during treatment and for several months after you stop using sofosbuvir, velpatasvir, and voxilaprevir.
Store this medicine in the original container at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking sofosbuvir, velpatasvir, and voxilaprevir?
If you also take an antacid, do not take it for at least 4 hours after you have taken your dose of sofosbuvir, velpatasvir, and voxilaprevir (with food).
Taking this medication will not prevent you from passing hepatitis C to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HCV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.
Sofosbuvir, velpatasvir, and voxilaprevir side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have new or worsening symptoms such as:
loss of appetite, upper stomach pain;
dark urine, clay-colored stools; or
jaundice (yellowing of the skin or eyes).
If you also take amiodarone: Seek medical help right away if you feel weak, tired, or light-headed, or if you have chest pain, shortness of breath, confusion, or memory problems.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect sofosbuvir, velpatasvir, and voxilaprevir?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Other drugs may interact with sofosbuvir, velpatasvir, and voxilaprevir, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
More about Vosevi (sofosbuvir / velpatasvir / voxilaprevir)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 0 Reviews – Add your own review/rating
- Drug class: antiviral combinations
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about sofosbuvir, velpatasvir, and voxilaprevir.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 1.01.
Date modified: January 03, 2018
Last reviewed: July 31, 2017