Generic Name: azacitidine (ay za SYE ti deen)
Brand Name: Vidaza
Medically reviewed on January 18, 2018.
What is azacitidine?
Azacitidine is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
Azacitidine is used to treat certain types of bone marrow cancers and blood cell disorders.
Azacitidine may also be used for purposes not listed in this medication guide.
You should not receive this medicine if you have advanced liver cancer.
Before taking this medicine
You should not receive this medicine if you are allergic to azacitidine or mannitol, or if you have:
advanced liver cancer.
To make sure azacitidine is safe for you, tell your doctor if you have ever had:
kidney disease; or
Azacitidine can harm an unborn baby. Both men and women using this medicine should use birth control to prevent pregnancy. The use of this medicine by either parent may cause birth defects.
If you are a woman, keep using birth control for at least 6 months after your last dose of azacitidine. If you are a man, keep using birth control for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using this medicine.
It is not known whether azacitidine passes into breast milk or if it could harm a nursing baby. Do not breast-feed while using azacitidine and for at least 1 week after your last dose.
How is azacitidine given?
Azacitidine is injected under the skin, or as an infusion into a vein. A healthcare provider will give you this injection.
This medicine is usually given for 7 days in a row every 4 weeks for at least 4 treatment cycles. Your treatment schedule may be different. Follow your doctor's instructions.
You may also be given medications to reduce nausea and vomiting.
If azacitidine accidentally gets on your skin, wash the area thoroughly with soap and warm water.
Azacitidine can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your kidney function may also need to be tested. Your cancer treatments may be delayed based on the results.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your azacitidine injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using azacitidine?
Do not receive a "live" vaccine while using azacitidine, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.
This medicine can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.
Azacitidine side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
redness, swelling, warmth, oozing, or other signs of skin infection;
stabbing chest pain, wheezing, cough with yellow or green mucus, feeling short of breath;
low blood cell counts--fever, chills, flu-like symptoms, swollen gums, mouth sores, skin sores, rapid heart rate, pale skin, easy bruising, unusual bleeding, feeling light-headed;
kidney problems--lower back pain, blood in your urine, little or no urinating, swelling in your feet or ankles;
liver problems--upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
Common side effects may include:
fever, chills, bruising, or other signs of low blood cell counts;
nausea, vomiting, constipation, diarrhea;
redness or other irritation where the injection was given.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect azacitidine?
Other drugs may interact with azacitidine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 8.01.
More about Vidaza (azacitidine)
- Vidaza Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 10 Reviews – Add your own review/rating
- Generic Availability
- Drug class: miscellaneous antineoplastics