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Viberzi

Generic Name: eluxadoline (EL ux AD oh leen)
Brand Name: Viberzi

Medically reviewed: April 26, 2017

What is eluxadoline?

Eluxadoline works directly in your intestines to slow the movement of food during digestion. Eluxadoline also makes the nerves in your intestines less sensitive to stimulation.

Eluxadoline is used to treat irritable bowel syndrome when the main symptom is diarrhea.

Eluxadoline may also be used for purposes not listed in this medication guide.

Important Information

You should not use eluxadoline if you have a pancreas disorder, severe liver disease, alcoholism, a blockage in your intestines, a gallbladder disorder, or if your gallbladder has been removed.

Before taking this medicine

You should not use eluxadoline if you are allergic to it, or if you have:

  • severe constipation or a blockage in your intestines;

  • a history of gallbladder obstruction, or if your gallbladder has been removed;

  • digestive problems caused by a muscle valve called the sphincter of Oddi (SFINK-ter of OD-dee);

  • severe liver disease;

  • a pancreas disorder; or

  • a habit of drinking more than 3 alcoholic beverages per day.

To make sure eluxadoline is safe for you, tell your doctor if you have:

  • liver disease.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether eluxadoline passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Eluxadoline is not approved for use by anyone younger than 18 years old.

How should I take eluxadoline?

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Take with food.

Call your doctor if your symptoms do not improve, or if they get worse.

Store at room temperature away from moisture and heat.

Eluxadoline may be habit-forming. Never share eluxadoline with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking eluxadoline?

Avoid drinking alcohol. It may increase your risk of pancreas problems.

Avoid taking anti-diarrhea medicine such as loperamide (Imodium) without your doctor's advice. Taking loperamide long-term while you are taking eluxadoline may cause severe constipation.

Eluxadoline side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop taking eluxadoline and call your doctor at once if you have:

  • new or worsening stomach pain (may be severe);

  • nausea and vomiting;

  • constipation lasting longer than 4 days; or

  • severe pain in your upper stomach spreading to your back.

Side effects may be more likely in older adults.

Common side effects may include:

  • constipation;

  • nausea; or

  • stomach pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect eluxadoline?

Tell your doctor about all your current medicines and any you start or stop using, especially:

This list is not complete. Other drugs may interact with eluxadoline, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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