Skip to Content

Tylenol Sore Throat Nighttime

Generic Name: acetaminophen and diphenhydramine (a SEET a MIN oh fen and DYE fen HYE dra meen)
Brand Name: Aceta-Gesic, Coricidin Night Time Cold Relief, Excedrin PM, Headache Relief PM, Legatrin PM, Mapap PM, Midol PM, Night Time Pain, Pain Relief PM Extra Strength, Percogesic Extra Strength, Tylenol Cold Relief Nighttime, Tylenol PM, Tylenol Sore Throat Nighttime, Unisom with Pain Relief

Medically reviewed on February 27, 2018

What is Tylenol Sore Throat Nighttime?

Acetaminophen is a pain reliever and a fever reducer.

Diphenhydramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Tylenol Sore Throat Nighttime is a combination medicine used to treat headache, runny nose, sneezing, watery eyes, and pain or fever caused by allergies, the common cold, or the flu.

Tylenol Sore Throat Nighttime may also be used for purposes not listed in this medication guide.

Important Information

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

In rare cases, acetaminophen may cause a severe skin reaction. Stop taking Tylenol Sore Throat Nighttime and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

Before taking this medicine

Ask a doctor before taking medicine that contains acetaminophen if you have ever had liver disease, or if you drink more than 3 alcoholic beverages per day.

You should not use this medication if you are allergic to it, or if you have:

  • severe constipation, blockage in your stomach or intestines;

  • untreated or uncontrolled diseases--glaucoma, asthma, heart disease, overactive thyroid; or

  • if you are unable to urinate.

Ask a doctor or pharmacist before taking this medicine if you have any medical condition, especially:

It is not known whether this medicine will harm an unborn baby. Do not use cold or allergy medicine without a doctor's advice if you are pregnant.

This medicine can pass into breast milk and may harm a nursing baby. Antihistamines may slow breast milk production. Do not use cold or allergy without a doctor's advice if you are breast-feeding a baby.

Always ask a doctor before giving a cold or allergy medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

How should I take Tylenol Sore Throat Nighttime?

Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not take Tylenol Sore Throat Nighttime for longer than recommended. Cold or allergy medicine is usually taken only for a short time until your symptoms clear up.

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

Stop taking the medicine and call your doctor if you still have a fever after 3 days, or you still have pain after 10 days (or 5 days if treating a child). Also call your doctor if your symptoms get worse, or if you have any redness or swelling.

If you need surgery or medical tests, tell the doctor ahead of time if you have taken this medicine within the past few days.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since this medicine is used when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

What should I avoid while taking Tylenol Sore Throat Nighttime?

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Tylenol Sore Throat Nighttime side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking Tylenol Sore Throat Nighttime and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.

Stop using the medicine and call your doctor at once if you have:

  • fast, pounding, or uneven heartbeats;

  • severe dizziness or drowsiness, slow or shallow breathing;

  • tremor, restless muscle movements;

  • little or no urinating;

  • flu symptoms, easy bruising, unusual bleeding, pale skin, feeling light-headed; or

  • nausea, pain in your upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • constipation;

  • dry eyes, blurred vision, dry mouth or nose;

  • mild dizziness or drowsiness, trouble concentrating;

  • feeling restless or excited (especially in children); or

  • mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Tylenol Sore Throat Nighttime?

Other drugs may interact with acetaminophen and diphenhydramine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

More about Tylenol Sore Throat Nighttime (acetaminophen / diphenhydramine)

Consumer resources

Other brands: Pain Relief PM Extra Strength, Legatrin PM, Mapap PM, Midol PM, ... +8 more

Other Formulations

Related treatment guides

Hide