Medically reviewed on March 15, 2017
What is trimethobenzamide?
Trimethobenzamide affects the areas of the brain that stimulate nausea and vomiting.
Trimethobenzamide may also be used for purposes not listed in this medication guide.
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Before taking this medicine
You should not use trimethobenzamide if you are allergic to it.
To make sure trimethobenzamide is safe for you, tell your doctor if you have:
liver disease; or
Do not give this medication to a child or teenager without medical advice, especially if the child has a fever, flu symptoms, or chicken pox. Trimethobenzamide is not approved for use by anyone younger than 18 years old.
It is not known whether trimethobenzamide will harm an unborn baby. Tell your doctor if you are pregnant.
It is not known whether trimethobenzamide passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.
How should I take trimethobenzamide?
Trimethobenzamide is usually taken 3 or 4 times per day. You may also be using the medicine only when needed. Follow all directions on your prescription label. Do not take trimethobenzamide in larger or smaller amounts or for longer than recommended.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Since trimethobenzamide is used when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking trimethobenzamide?
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Avoid drinking alcohol. It may increase certain side effects of trimethobenzamide.
Trimethobenzamide side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using trimethobenzamide and call your doctor at once if you have:
twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
trouble speaking or swallowing;
pain, stiffness, or unusual muscle spasm in your neck;
tremors, feeling restless or being unable to sit still;
a seizure (convulsions); or
jaundice (yellowing of the skin or eyes).
Serious side effects may be more likely in older adults and those who are ill or debilitated.
Common side effects may include:
headache, muscle cramps;
confusion, depressed mood;
blurred vision; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Trimethobenzamide dosing information
Usual Adult Dose for Nausea/Vomiting:
Oral: 300 mg orally 3 or 4 times a day
IM Injection: 200 mg IM 3 or 4 times a day
Comment: Dosage should be adjusted according to the therapy indication, symptom severity, and patient response.
-Treatment of postoperative nausea and vomiting
-Treatment of nausea associated with gastroenteritis
What other drugs will affect trimethobenzamide?
Taking trimethobenzamide with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking a sleeping pill, narcotic medication, muscle relaxer, or medicine for anxiety, depression, mental illness, or seizures.
Other drugs may interact with trimethobenzamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 8.01.
More about trimethobenzamide
- Trimethobenzamide Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- 6 Reviews
- Drug class: anticholinergic antiemetics
- Trimethobenzamide Capsules
- Trimethobenzamide Injection Solution
- Trimethobenzamide (Advanced Reading)
- Trimethobenzamide Intramuscular (Advanced Reading)