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Generic Name: tolazamide (tole AZ a mide)
Brand Name: Tolinase
Medically reviewed: October 16, 2017
What is Tolinase?
Tolinase is an oral diabetes medicine that helps control blood sugar levels. This medicine helps your body respond better to insulin produced by your pancreas.
Tolinase is used together with diet and exercise to treat type 2 diabetes. Other diabetes medicines are sometimes used in combination with this medicine if needed.
Tolinase should not be used by itself to treat type 1 diabetes.
Tolinase may also be used for purposes not listed in this medication guide.
Before taking this medicine
You should not use this medicine if you are allergic to Tolinase, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
To make sure Tolinase is safe for you, tell your doctor if you have:
kidney disease; or
a history of heart disease.
Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of taking Tolinase.
It is not known whether Tolinase will harm an unborn baby. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.
It is not known whether Tolinase passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
How should I take Tolinase?
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Tolinase is usually taken once a day, with breakfast or the first main meal of the day. Follow your doctor's instructions.
Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.
Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, confusion, irritability, dizziness, or feeling shaky. Always keep a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, hard candy, crackers, raisins, and non-diet soda. Be sure your family and close friends know how to help you in an emergency.
If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. Your doctor can prescribe a glucagon emergency injection kit and tell you how to use it.
Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change. Do not change your medication dose or schedule without your doctor's advice.
Use Tolinase regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Tolinase is only part of a treatment program that may also include diet, exercise, weight control, regular blood sugar testing, and special medical care. Follow your doctor's instructions very closely.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember (be sure to take the medicine with food). Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A Tolinase overdose can cause life-threatening hypoglycemia.
Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).
What should I avoid while taking Tolinase?
Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.
Tolinase side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
severe skin rash, redness, or itching;
easy bruising or bleeding,
pale or yellowed skin, dark colored urine;
low blood sugar--headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery; or
low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Tolinase?
You may be more likely to have hypoglycemia (low blood sugar) if you take Tolinase with other drugs that can lower blood sugar, such as:
sulfa drugs (Bactrim, SMZ-TMP, and others);
a monoamine oxidase inhibitor (MAOI); or
insulin or other oral diabetes medications.
This list is not complete, and many other medicines can increase or decrease the effects of Tolinase on lowering your blood sugar. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with this medicine. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 3.12.
More about Tolinase (tolazamide)
- Tolinase Side Effects
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- Support Group
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- Drug class: sulfonylureas