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Tecfidera

Generic Name: dimethyl fumarate (dye METH il FUE mar ate)
Brand Name: Tecfidera

What is dimethyl fumarate?

Dimethyl fumarate is used to treat relapsing multiple sclerosis.

Dimethyl fumarate may also be used for purposes not listed in this medication guide.

Important Information

Dimethyl fumarate may cause a serious viral infection of the brain that can lead to disability or death. Call your doctor right away if you have any change in your mental state, decreased vision, weakness on one side of your body, or problems with speech or walking. These symptoms may start gradually and get worse quickly.

Before taking this medicine

You should not use dimethyl fumarate if you are allergic to it.

To make sure dimethyl fumarate is safe for you, tell your doctor if you have:

  • an active infection; or

  • low white blood cell (WBC) counts.

It is not known whether dimethyl fumarate will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of dimethyl fumarate on the baby.

It is not known whether dimethyl fumarate passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take dimethyl fumarate?

Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using dimethyl fumarate.

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take dimethyl fumarate with or without food. Taking the medicine with food may help prevent flushing (warmth, itching, or burning sensations).

Do not crush, chew, break, or open a dimethyl fumarate capsule. Swallow it whole.

Dimethyl fumarate is usually given in two different strengths, one for a starter dose and the other for a maintenance dose. The starter dose is usually taken for only 7 days. Follow your doctor's dosing instructions very carefully.

While using dimethyl fumarate, you will need frequent blood tests.

Store at room temperature away from moisture, heat, and light. Throw away any unused capsules 90 days after you first opened the bottle.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking dimethyl fumarate?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Dimethyl fumarate side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Dimethyl fumarate may cause a serious viral infection of the brain that can lead to disability or death. Symptoms may start gradually and get worse quickly. Call your doctor right away if you have:

  • any change in your mental state;

  • decreased vision;

  • weakness on one side of your body; or

  • problems with speech or walking.

Call your doctor at once if you have:

  • fever, pain when swallowing, cold or flu symptoms;

  • severe redness or feelings of warmth, tingling, itching, or burning; or

  • liver problems--loss of appetite, upper stomach pain (right side), tiredness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect dimethyl fumarate?

Other drugs may interact with dimethyl fumarate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

  • Your pharmacist can provide more information about dimethyl fumarate.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 4.01.

Date modified: February 01, 2018
Last reviewed: December 26, 2017

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