Promethazine with Dextromethorphan
Medically reviewed on December 15, 2017.
What is Promethazine with Dextromethorphan?
Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.
Promethazine is an antihistamine. It blocks the effects of the naturally occurring chemical histamine in your body.
Promethazine with Dextromethorphan may also be used for purposes other than those listed in this medication guide.
Call your doctor immediately if you experience uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects.
Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.
Do not use Promethazine with Dextromethorphan if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take this medicine before the MAO inhibitor has cleared from your body.
Do not use any other over-the-counter cough, cold, or allergy medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains dextromethorphan.
Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema.
Before taking this medicine
Do not use Promethazine with Dextromethorphan if you have asthma or other lung disease.
Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take a cough or cold medicine before the MAO inhibitor has cleared from your body.
Before taking Promethazine with Dextromethorphan, tell your doctor if you are allergic to any drugs, or if you have emphysema or chronic bronchitis. You may not be able to use this medication, or you may need a dosage adjustment or special tests during treatment.
Before taking Promethazine with Dextromethorphan, tell your doctor if you have:
epilepsy or another seizure disorder;
emphysema or chronic bronchitis;
sleep apnea (breathing stops during sleep);
a stomach ulcer or digestive obstruction;
bone marrow disorder;
problems with urination;
high blood pressure or heart disease; or
If you have any of these conditions, you may not be able to use Promethazine with Dextromethorphan, or you may need a dosage adjustment or special tests during treatment.
FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether this medication passes into breast milk or if it could harm an unborn baby. Do not use Promethazine with Dextromethorphan without telling your doctor if you are breast-feeding a baby.
How should I take Promethazine with Dextromethorphan?
Take this medication exactly as it has been prescribed by your doctor. Do not use the medication in larger amounts, or use it for longer than recommended. Follow the directions on your prescription label. Cough or cold medicine is usually taken only for a short time until your symptoms clear up.
Always ask a doctor before giving cough or cold medicine to a child. Death can occur from the misuse of cough or cold medicine in very young children.
Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
If you need to have any type of surgery, tell the surgeon ahead of time if you have taken a cough medicine within the past few days.
Store Promethazine with Dextromethorphan at room temperature, away from heat, light, and moisture.
What happens if I miss a dose?
Since cough and cold medicine is usually taken only as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine.
Symptoms of a Promethazine with Dextromethorphan overdose may include feeling restless or nervous, severe drowsiness, dizziness, dry mouth, large pupils, flushing, nausea, vomiting, shallow breathing, and fainting.
What should I avoid while taking Promethazine with Dextromethorphan?
This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Avoid drinking alcohol. It can increase some of the side effects of Promethazine with Dextromethorphan.
Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with cough medicine can increase your risk of unpleasant side effects.
Do not use any other over-the-counter cough, cold, or allergy medication without first asking your doctor or pharmacist. Dextromethorphan is contained in many medicines available over the counter. If you take certain products together you may accidentally take too much of this medicine. Read the label of any other medicine you are using to see if it contains dextromethorphan.
Promethazine with Dextromethorphan side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using Promethazine with Dextromethorphan and call your doctor at once if you have any of these serious side effects:
uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
tremors, twitching, or uncontrolled muscle movements in your face, arms, or legs.
severe dizziness, anxiety, restless feeling, or nervousness;
hallucinations (seeing or hearing things);
confusion, hallucinations; or
slow, shallow breathing, weak pulse;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
fever, muscle stiffness, confusion, fast or uneven heartbeat, sweating, fainting.
Keep taking Promethazine with Dextromethorphan and talk with your doctor if you have any of these less serious side effects:
dizziness, drowsiness, sleepiness, or confusion;
blurred vision, dry mouth;
ringing in your ears;
nausea or vomiting; or
increased sensitivity to sunlight.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Promethazine with Dextromethorphan?
Before taking Promethazine with Dextromethorphan, tell your doctor if you are using any of the following drugs:
quinidine (Quinaglute, Quinidex);
medicines to treat high blood pressure;
antidepressant medications such as amitriptyline (Elavil, Etrafon), bupropion (Wellbutrin, Zyban), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), imipramine (Janimine, Tofranil), paroxetine (Paxil), sertraline (Zoloft), and others.
atropine (Donnatal, and others), belladonna, clidinium (Quarzan), dicyclomine (Bentyl), glycopyrrolate (Robinul), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), methscopolamine (Pamine), and scopolamine (Transderm-Scop).
If you are using any of these drugs, you may not be able to use Promethazine with Dextromethorphan, or you may need dosage adjustments or special tests during treatment.
There may be other drugs not listed that can affect Promethazine with Dextromethorphan. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
- Your pharmacist has information about Promethazine with Dextromethorphan written for health professionals that you may read.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 2.07.
More about Promethazine with Dextromethorphan (dextromethorphan / promethazine)
- Promethazine with Dextromethorphan Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
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- Drug class: upper respiratory combinations
Other brands: Promethazine with DM