Generic Name: abatacept (a BAY ta sept)
Brand Name: Orencia
What is abatacept?
Abatacept a protein that prevents your body's immune system from attacking healthy tissues such as joints. The immune system helps your body fight infections. In people with autoimmune disorders, the immune system mistakes the body's own cells for invaders and attacks them.
Abatacept is used to treat the symptoms of rheumatoid arthritis, and to prevent joint damage caused by these conditions. This medicine is for adults and children who are at least 2 years old.
Abatacept is not a cure for any autoimmune disorder and will only treat the symptoms of your condition.
Abatacept may also be used for purposes not listed in this medication guide.
What is the most important information I should know about abatacept?
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
What should I discuss with my healthcare provider before using abatacept?
You should not use abatacept if you are allergic to it.
Before using abatacept, tell your doctor if you have ever had tuberculosis, if anyone in your household has tuberculosis, or if you have recently traveled to an area where tuberculosis is common.
To make sure abatacept is safe for you, tell your doctor if you have:
a weak immune system;
any type of infection including a skin infection or open sores;
infections that go away and come back;
COPD (chronic obstructive pulmonary disease);
if you have ever had hepatitis; or
if you are scheduled to receive any vaccines.
Using abatacept may increase your risk of developing certain types of cancer such as lymphoma (cancer of the lymph nodes). This risk may be greater in older adults. Talk to your doctor about your specific risk.
It is not known whether abatacept will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of abatacept on the baby.
It is not known whether abatacept passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.
Children using abatacept should be current on all childhood immunizations before starting treatment.
How should I use abatacept?
Before you start treatment with abatacept, your doctor may perform tests to make sure you do not have tuberculosis or other infections.
Abatacept is injected under the skin, or into a vein through an IV. You may be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.
Abatacept is injected under the skin when given to a child between 2 and 6 years old.
Abatacept must be given slowly when infected into a vein, and the IV infusion can take at least 30 minutes to complete.
This medicine is usually given every 1 to 4 weeks. Follow your doctor's instructions.
You may need to mix abatacept with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medication.
Do not shake the medication bottle or you may ruin the medicine. Prepare your dose only when you are ready to give an injection. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.
Each single-use vial (bottle) or prefilled syringe of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.
Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.
If you need surgery, tell the surgeon ahead of time that you are using abatacept.
If you have ever had hepatitis B, abatacept can cause this condition to come back or get worse. You will need frequent blood tests to check your liver function during treatment and for several months after you stop using this medicine.
This medicine can cause false results with certain blood glucose tests, showing high blood sugar readings. If you have diabetes, talk to your doctor about the best way to check your blood sugar while you are using abatacept.
Autoimmune disorders are often treated with a combination of different drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.
Store abatacept in the refrigerator. Do not freeze. Keep the medicine in original carton to protect it from light. Do not use abatacept if the expiration date on the medicine label has passed.
If you need to transport the medicine, place the syringes in a cooler with ice packs.
Abatacept that has been mixed with a diluent may be stored in a refrigerator or at room temperature and used within 24 hours.
What happens if I miss a dose?
Call your doctor for instructions if you miss your abatacept dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using abatacept?
Do not receive a "live" vaccine while using abatacept, and for at least 3 months after your treatment ends. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.
Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.
Abatacept side effects
Some side effects may occur during the injection. Tell your caregiver right away if you feel dizzy, light-headed, itchy, or have a severe headache or trouble breathing within 1 hour after receiving the injection.
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Serious and sometimes fatal infections may occur during treatment with abatacept. Stop using this medicine and call your doctor right away if you have signs of infection such as:
fever, chills, night sweats, flu symptoms, weight loss;
feeling very tired;
dry cough, sore throat; or
warmth, pain, or redness of your skin.
Call your doctor at once if you have any of these other serious side effects:
stabbing chest pain, wheezing, cough with yellow or green mucus;
pain or burning when you urinate; or
signs of skin infection such as itching, swelling, warmth, redness, or oozing.
Common side effects may include:
nausea, diarrhea, stomach pain;
cold symptoms such as stuffy nose, sneezing, sore throat, cough.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect abatacept?
Tell your doctor about all your current medicines and any you start or stop using, especially:
rituximab (Rituxan); or
This list is not complete. Other drugs may interact with abatacept, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More about Orencia (abatacept)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 24 Reviews – Add your own review/rating
- Drug class: antirheumatics
Related treatment guides
Where can I get more information?
- Your doctor or pharmacist can provide more information about abatacept.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 7.01.
Date modified: June 01, 2017
Last reviewed: April 04, 2017