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Generic Name: gadoversetamide (GAD oh ver SET a mide)
Brand Name: OptiMARK

Medically reviewed on January 2, 2018

What is OptiMARK?

OptiMARK is a contrast agent. It is used in combination with magnetic resonance imagining (MRI) to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on the MRI.

OptiMARK is used to help diagnose certain disorders of the brain and spine (central nervous system), or the liver.

OptiMARK may also be used for purposes not listed in this medication guide.

Important Information

OptiMARK can cause a life-threatening condition in people with advanced kidney disease. Before receiving this medicine, tell your doctor if you have kidney disease or if you are on dialysis. You may not be able to receive this medicine. Also tell your doctor if you have recently received any contrast agents similar to this medicine.

Before taking this medicine

OptiMARK can cause a life-threatening condition in people with advanced kidney disease. You should not receive this medication if you have kidney disease or if you are on dialysis.

OptiMARK can stay in your body for months or years after you receive this medicine. It is not known whether this could cause any health problems in people whose kidneys work properly. Tell your doctor if you have had repeated scans with a contrast agent, and provide the date of your last scan.

You should not receive OptiMARK if you are allergic to it.

To make sure OptiMARK is safe for you, tell your doctor if you have ever had:

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether OptiMARK passes into breast milk or if it could harm a nursing baby. Do not breast-feed for at least 72 hours after receiving this medicine. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.

How is gadoversetamide given?

OptiMARK is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting during your MRI.

Your doctor or other healthcare provider may want to watch you for a short time after your test is over. This is to make sure you do not have any unwanted side effects or delayed reactions.

OptiMARK can cause you to have unusual results with certain medical tests for up to 24 hours after your MRI. Tell any doctor who treats you that you have received this medicine.

What happens if I miss a dose?

Since OptiMARK is used only during your MRI, you will not be on a dosing schedule.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving OptiMARK?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

OptiMARK side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects of OptiMARK may occur up to several days after injection.

OptiMARK can cause a life-threatening condition in people with advanced kidney disease. Call your doctor right away if you have any symptoms of this condition, such as:

  • burning, itching, swelling, scaling, and tightening or hardening of your skin;

  • muscle weakness;

  • joint stiffness in your arms, hands, legs, or feet;

  • deep bone pain in your ribs or your hips;

  • trouble moving; or

  • skin redness or discoloration.

Also call your doctor at once if you have:

  • kidney problems--little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath;

  • a seizure (convulsions); or

  • fast, uneven heart rate.

Common side effects may include:

  • headache, dizziness;

  • nausea;

  • flushing (warmth, redness, or tingly feeling);

  • unusual or unpleasant taste in your mouth; or

  • numbness, burning pain, or tingling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect OptiMARK?

Other drugs may interact with gadoversetamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.