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Ocriplasmin ophthalmic

Generic name: ocriplasmin ophthalmic (OK ri PLAZ min)
Brand name: Jetrea
Dosage forms: intravitreal solution (0.375 mg/0.3 mL)
Drug class: Miscellaneous ophthalmic agents

Medically reviewed by on Dec 11, 2019. Written by Cerner Multum.

What is ocriplasmin ophthalmic?

Ocriplasmin is used to treat an eye condition called symptomatic vitreomacular adhesion (sVMA).

As a normal part of aging, the gel-like substance (vitreous) inside the eye becomes more liquid and begins to pull away from the retina, located at the back of the eye. This is called posterior vitreous detachment. sVMA occurs when small areas of the vitreous remain attached to the retina, causing the retina to pull away from its normal location. sVMA can cause distorted vision, decreased vision, or loss of central vision in severe cases.

Ocriplasmin ophthalmic may also be used for purposes not listed in this medication guide.


Call your doctor at once if you have eye pain or redness, changes in vision, or if your eyes are more sensitive to light.

Before taking this medicine

Tell your doctor if you are pregnant or breastfeeding.

How is ocriplasmin ophthalmic given?

Ocriplasmin ophthalmic is given as an injection into your eye. Your doctor will use a medicine to numb your eye before giving you the injection. You will receive this injection in your doctor's office or other clinic setting.

What happens if I miss a dose?

Ocriplasmin is used as a single dose and does not have a daily dosing schedule.

What happens if I overdose?

Since ocriplasmin ophthalmic is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving ocriplasmin ophthalmic?

This medicine may cause blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.

Ocriplasmin ophthalmic side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • eye pain or redness;

  • vision changes;

  • yellowish vision; or

  • if your eyes are more sensitive to light.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ocriplasmin ophthalmic dosing information

Usual Adult Dose for Vitreomacular Adhesion:

0.125 mg (0.1 mL of the diluted solution) via intravitreal injection to the affected eye ONCE as a single dose

-Each drug vial should only be used once and for the treatment of a single eye.
-This drug should be administered by a qualified physician.
-The manufacturer product information should be consulted regarding administration.

Use: Treatment of symptomatic vitreomacular adhesion

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What other drugs will affect ocriplasmin ophthalmic?

Other drugs may affect ocriplasmin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

More about ocriplasmin ophthalmic

Consumer resources

Other brands

Professional resources

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.