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Novolog Mix 70/30 PenFill

Generic Name: insulin aspart and insulin aspart protamine (IN su lin AS part, IN su lin AS part PRO ta meen)
Brand Name: NovoLOG Mix 70/30, NovoLOG Mix 70/30 FlexPen, NovoLOG Mix 70/30 PenFill

Medically reviewed on May 11, 2017

What is Novolog Mix 70/30 PenFill (insulin aspart and insulin aspart protamine)?

Insulin is a hormone that is produced in the body. It works by lowering levels of glucose (sugar) in the blood. Insulin aspart and insulin aspart protamine is a faster-acting form of insulin than regular human insulin.

Insulin aspart and insulin aspart protamine is a combination medicine used to treat type 1 (insulin-dependent) diabetes in adults.

Insulin aspart and insulin aspart protamine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about this medicine?

You should not use insulin aspart and insulin aspart protamine if you are having an episode of hypoglycemia (low blood sugar).

What should I discuss with my healthcare provider before using this medicine?

You should not use this medicine if you are allergic to insulin, or if you are having an episode of hypoglycemia (low blood sugar).

To make sure this medicine is safe for you, tell your doctor if you have liver or kidney disease.

FDA pregnancy category B. Insulin aspart and insulin aspart protamine is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether this medicine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I use this medicine?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Insulin is injected under the skin. You will be shown how to use injections at home. Do not self inject this medicine if you do not understand how to give the injection and properly dispose of used needles and syringes.

Insulin aspart and insulin aspart protamine must not be given with an insulin pump, or mixed with other insulins.

Your care provider will show you the best places on your body to inject the medicine. Do not inject into the same place two times in a row.

After using insulin aspart and insulin aspart protamine, you should eat a meal within 15 minutes. This medicine is usually given with 2 meals per day.

Never share an injection pen or cartridge with another person. Sharing injection pens or cartridges can allow disease such as hepatitis or HIV to pass from one person to another.

Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.

Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, confusion, irritability, dizziness, or feeling shaky. Always keep a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, hard candy, crackers, raisins, and non-diet soda. Be sure your family and close friends know how to help you in an emergency.

If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. Your doctor can prescribe a glucagon emergency injection kit and tell you how to use it.

Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss.

Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change. Do not change your medication dose or schedule without your doctor's advice.

Insulin is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.

Storing unopened vials or injection pens: Keep in the carton and store in a refrigerator, protected from light. Throw away any insulin not used before the expiration date on the medicine label.

Unopened vials or injection pens may also be stored at room temperature for up to 28 days, away from heat and bright light. Throw away any insulin not used within 28 days.

Storing vials after your first use: You may keep "in-use" vials in the refrigerator, protected from light. Use within 28 days.

You may also keep in-use" vials at room temperature. Use within 28 days. Protect from light.

Storing injection pens after your first use: Keep the "in-use" injection pen at room temperature and use within 28 days. Do not refrigerate. Protect from light.

Do not freeze insulin, and throw away the medicine if it has become frozen.

What happens if I miss a dose?

Since this medicine is used before meals, you may not be on a timed dosing schedule. Whenever you use this medication, be sure to eat a meal within 15 minutes. Do not use extra medicine to make up a missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

What should I avoid while using this medicine?

Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

Novolog Mix 70/30 PenFill (insulin aspart and insulin aspart protamine) side effects

Get emergency medical help if you have any of these signs of insulin allergy: itching skin rash over the entire body, wheezing, trouble breathing, fast heart rate, sweating, or feeling like you might pass out.

Call your doctor at once if you have:

  • vision changes;

  • swelling in your hands or feet;

  • itching, swelling, redness, or thickening of the skin where you injected the medicine; or

  • low potassium--confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling.

Common side effects may include:

  • low blood sugar--headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Novolog Mix 70/30 PenFill (insulin aspart and insulin aspart protamine)?

Many other medicines can increase or decrease the effects of insulin on lowering your blood sugar. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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