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Generic Name: nesiritide (ness EAR a tide)
Brand Name: Natrecor

Medically reviewed by on Apr 2, 2018 – Written by Cerner Multum

What is nesiritide?

Nesiritide relaxes and dilates blood vessels, lowering blood pressure.

Nesiritide is used to improve breathing in people with congestive heart failure (CHF).

Nesiritide may also be used for purposes not listed in this medication guide.

Important Information

You should not use nesiritide if you have very low blood pressure.

Tell your doctor about any heart problems you currently have or have had in the past. There are certain heart conditions that could make it dangerous for you to receive nesiritide.

Before taking this medicine

You should not receive this medicine if you are allergic to nesiritide, or if you have very low blood pressure.

To make sure you can safely receive nesiritide, tell your doctor if you have kidney disease.

Tell your doctor about any heart problems you currently have or have had in the past. There are certain heart conditions that could make it dangerous for you to receive nesiritide.

FDA pregnancy category C. It is not known whether nesiritide will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether nesiritide passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How is nesiritide given?

Nesiritide is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting.

Nesiritide must be given slowly through an IV infusion. The needle will remain in place while you receive the medication continuously for up to 48 hours.

Your blood pressure will be checked often while you are receiving nesiritide.

What happens if I miss a dose?

Since nesiritide is given by a healthcare professional in a medical setting, you are not likely to miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid after receiving nesiritide?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Nesiritide side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have:

  • confusion, feeling light-headed, fainting;

  • fast, slow, or irregular heartbeats;

  • urinating less than usual;

  • chest pain; or

  • fever, unusual weakness or tiredness.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Nesiritide dosing information

Usual Adult Dose for Congestive Heart Failure:

Initial dose: 2 mcg/kg IV bolus, followed by 0.01 mcg/kg/min via continuous IV infusion; not to be titrated more frequently than every 3 hours to a maximum of 0.03 mcg/kg/min

-This drug should not be initiated at a dose higher than the initial recommended dose.
-The loading dose may not be appropriate for those with systolic blood pressure less than 110 mmHg or for patients recently treated with afterload reducers.
-There is limited experience with administering this drug for longer than 96 hours; monitor blood pressure closely during administration.

Use: For the treatment of acutely decompensated heart failure in patients who have dyspnea at rest or with minimal activity

What other drugs will affect nesiritide?

Tell your doctor about all other medicines you use, especially medication to treat high blood pressure (hypertension).

Other drugs may interact with nesiritide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.