Generic Name: methyl aminolevulinate (topical) (METH il a MEE noe LEV ue LIN ate)
Brand Name: Metvixia
What is methyl aminolevulinate?
Methyl aminolevulinate makes your skin more sensitive to light. It works by causing a reaction with light that can destroy certain types of diseased skin cells.
Methyl aminolevulinate topical (for the skin) is used in combination with red light therapy to treat a skin condition called actinic keratosis of the face and scalp.
Methyl aminolevulinate may also be used for other purposes not listed in this medication guide.
What is the most important information I should know about methyl aminolevulinate?
You should not use this medicine if you are allergic to porphyrins, peanuts or almonds, or if your skin is especially sensitive to light.
What should I discuss with my health care provider before receiving methyl aminolevulinate?
You should not use this medicine if you are allergic to methyl aminolevulinate, or if you have:
an allergy to peanuts or almonds;
an allergy to porphyrins; or
if your skin is especially sensitive to light.
To make sure methyl aminolevulinate is safe for you, tell your doctor if you have:
a bleeding disorder; or
a history of skin cancer or skin growths.
FDA pregnancy category C. It is not known whether methyl aminolevulinate will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.
It is not known whether methyl aminolevulinate passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How is methyl aminolevulinate used?
Methyl aminolevulinate topical is a cream that is applied to your skin lesions before you receive red light treatment. A healthcare provider will apply this medicine in a clinical setting.
Before this medicine is applied, your skin lesions will be gently scraped to remove any scales or crusting. After methyl aminolevulinate is applied, your caregiver will cover the treatment area with a bandage. You will need to leave this bandage in place for 3 hours.
During this 3-hour period, avoid exposure to cold temperatures and sunlight or bright indoor lights. Wear a wide-brimmed hat if you must be outdoors during this time.
After your bandaging is removed, any excess medication will be removed with a saline solution. You will then be ready to receive the light treatment.
You will be given eye-wear to protect your eyes during red light treatment.
You may feel a slight stinging or burning during light therapy. Tell your caregivers if you have any type of severe discomfort.
Methyl aminolevulinate and red light therapy is usually given in two sessions one week apart. Your treatment schedule may be different. Follow your doctor's instructions.
It may take several weeks before you notice improvement in your skin condition. Your doctor will need to check your treated skin 3 months after the end of your last treatment with methyl aminolevulinate.
Your skin lesions may need to be treated more than once, and they may come back after treatment. Talk to your doctor about the number of treatments needed to treat your condition.
What happens if I miss a dose?
Because methyl aminolevulinate is applied only when needed prior to red light therapy, you will not be on a dosing schedule.
What happens if I overdose?
Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid while using methyl aminolevulinate?
Tell your caregivers right away if any of this medicine gets into your eyes, mouth, or nose.
Avoid touching the treated skin areas after methyl aminolevulinate cream has been applied to them. Special gloves must be worn by the healthcare provider while applying this medication, and you should not allow your own fingers to come into contact with the cream on your skin.
For at least 48 hours after your treatment, avoid exposing treated skin to sunlight, sunlamps, tanning beds, or other bright lights. Sunscreen is not effective enough to protect treated skin from harm caused by bright light during this time. Wear protective clothing whenever you are outdoors.
Even if you do not receive the light therapy portion of your treatment, you must still protect your skin from light for 48 hours after the cream was applied.
Methyl aminolevulinate side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
severe stinging, burning, redness, oozing, or swelling of treated skin areas (especially if these effects get worse or last longer than 3 weeks).
Common side effects may include:
skin redness, warmth, burning, stinging, or swelling;
blisters, skin ulcers; or
peeling or crusting of treated skin.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect methyl aminolevulinate?
It is not likely that other drugs you take orally or inject will have an effect on topically applied methyl aminolevulinate. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.
See also: Side effects (in more detail)
More about Metvixia (methyl aminolevulinate topical)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Español
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- Drug class: topical photochemotherapeutics
Related treatment guides
Where can I get more information?
- Your doctor or pharmacist can provide more information about methyl aminolevulinate.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 1.04.
Last reviewed: September 11, 2014
Date modified: October 13, 2017