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Mavyret

Generic Name: glecaprevir and pibrentasvir (glec A pre vir and pi BRENT as vir)
Brand Name: Mavyret

Medically reviewed on August 11, 2017

What is glecaprevir and pibrentasvir?

Glecaprevir and pibrentasvir are antiviral medications that prevent hepatitis C virus (HCV) from multiplying in your body.

Glecaprevir and pibrentasvir is a combination medicine used to treat chronic hepatitis C in adults with HCV genotype 1, 2, 3, 4, 5, or 6.

Glecaprevir and pibrentasvir is sometimes given after other medicines have been tried without success.

Glecaprevir and pibrentasvir may also be used for purposes not listed in this medication guide.

Important Information

You should not use this medicine if you have severe liver disease, or if you also take atazanavir or rifampin.

If you have ever had hepatitis B, glecaprevir and pibrentasvir can cause this condition to come back or get worse. You will need frequent blood tests to check your liver function.

Before taking this medicine

You should not use this medicine if you are allergic to glecaprevir or pibrentasvir, or if:

  • you have severe liver disease; or

  • you also take atazanavir or rifampin.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

  • hepatitis B;

  • liver problems other than hepatitis; or

  • HIV (human immunodeficiency virus).

It is not known whether glecaprevir and pibrentasvir will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether glecaprevir and pibrentasvir passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

How should I take glecaprevir and pibrentasvir?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Glecaprevir and pibrentasvir is usually taken as 3 tablets once per day for 8 to 16 weeks.

Take with food.

You will need frequent blood tests to check your liver function.

Hepatitis C is often treated with a combination of drugs. Use all medications as directed by your doctor. Read all patient information, medication guides, and instruction sheets provided to you. Do not change your doses or medication schedule without your doctor's advice. Every person with chronic hepatitis C should remain under the care of a doctor.

You should not stop using glecaprevir and pibrentasvir suddenly. Stopping suddenly could make your condition harder to treat with hepatitis C antiviral medicine.

If you have ever had hepatitis B, glecaprevir and pibrentasvir can cause this condition to come back or get worse. You will need liver function tests during treatment and for several months after you stop using this medicine.

Store this medicine in the original container at room temperature away from moisture and heat. Keep each tablet in the foil blister pack until you are ready to take it.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If you are more than 18 hours late, skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking glecaprevir and pibrentasvir?

Taking this medication will not prevent you from passing hepatitis C to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HCV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Glecaprevir and pibrentasvir side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • slow heartbeats;

  • weak or shallow breathing; or

  • low red blood cells--pale skin, weakness, rapid heart rate, trouble concentrating.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect glecaprevir and pibrentasvir?

Tell your doctor about all your current medicines and any you start or stop using, especially:

This list is not complete. Other drugs may interact with glecaprevir and pibrentasvir, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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