Generic Name: leuprolide and norethindrone (LOO proe lide and NOR eth IN drone)
Brand Name: Lupaneta Pack
What is Lupaneta Pack?
Lupaneta Pack is a combination medicine used to treat symptoms of endometriosis (overgrowth of uterine lining outside of the uterus).
Leuprolide helps treat pain caused by endometriosis.
Norethindrone helps prevent thinning bones (a side effect of leuprolide).
Lupaneta Pack is not for use in women who are older than 65.
Lupaneta Pack may also be used for purposes not listed in this medication guide.
You should not use Lupaneta Pack if you have: undiagnosed vaginal bleeding, liver disease or liver cancer, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.
Do not use if you are pregnant or breast-feeding.
Before taking this medicine
You should not use this medicine if you are allergic to leuprolide or norethindrone, or if you have:
abnormal vaginal bleeding that has not been checked by a doctor;
liver disease or liver cancer;
a history of heart attack, stroke, or blood clot; or
a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.
Tell your doctor if you have ever had:
osteoporosis or low bone mineral density (in you or a family member);
kidney disease; or
if you smoke.
You may need to have a negative pregnancy test before starting this treatment.
Do not use Lupaneta Pack if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine. Tell your doctor right away if you become pregnant.
Do not use a hormonal form of birth control (pills, injections, implants, skin patches, vaginal rings) to prevent pregnancy while you are receiving leuprolide injections. Use nonhormonal birth control such as a copper intrauterine device (IUD), or a condom or diaphragm with spermicide.
Leuprolide is likely to cause you not to ovulate or have menstrual periods during the 6-month treatment period. However, you may still be able to get pregnant.
Do not breast-feed while using this medicine.
Lupaneta Pack is not approved for use by anyone younger than 18 years old.
How should I take Lupaneta Pack?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
This medication is a combined treatment that includes a leuprolide injection and norethindrone tablets taken by mouth. A healthcare provider will give you the leuprolide injection. You will take the norethindrone tablets at home.
Leuprolide is usually given as a single injection into a muscle every 1 to 3 months for up to 6 months. Norethindrone tablets are taken every day for 1 to 3 months after your leuprolide injection.
You may have worsening symptoms of endometriosis when you first start using Lupaneta Pack. Symptoms should improve as you continue to use the medicine. Call your doctor if your symptoms do not eventually begin to improve.
You will need frequent medical tests.
Lupaneta Pack can affect the results of certain medical tests. Tell any doctor who treats you that you are using Lupaneta Pack.
Store norethindrone tablets at room temperature away from moisture and heat.
Based on your response to Lupaneta Pack treatment, your doctor may want you to have a second 6-month treatment.
What happens if I miss a dose?
Take the missed norethindrone dose as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Call your doctor for instructions if you miss an appointment for your leuprolide injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using Lupaneta Pack?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Lupaneta Pack side effects
Get emergency medical help if you have signs of an allergic reaction: hives, skin redness, severe itching; fast or pounding heartbeats; sweating, feeling like you might pass out; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.
Seek medical attention if you have signs of a pituitary gland problem: headache, vision problems, vomiting, changes in your mental status, severe weakness, cold or clammy skin, weak pulse, or feeling like you might pass out.
Call your doctor at once if you have:
sudden vision problems, sudden eye changes or discomfort;
sudden and severe headache;
mood changes, depression;
swelling, rapid weight gain;
ongoing symptoms of endometriosis;
chest pain or pressure, pain spreading to your jaw or shoulder;
liver problems--loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes); or
Common side effects may include:
minor vaginal bleeding or spotting, vaginal discharge or itching;
hot flashes, sweating;
feeling anxious or nervous;
sleep problems (insomnia);
weight gain; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Lupaneta Pack?
Tell your doctor about all your other medicines, especially:
seizure medication; or
steroids (prednisone and others).
This list is not complete. Other drugs may affect Lupaneta Pack, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 2.01.
More about Lupaneta Pack (leuprolide / norethindrone)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- Drug class: sex hormone combinations