Generic name: lucinactant (loo SIN AK tant )
Brand name: Surfaxin
Drug class: Lung surfactants
What is lucinactant?
Lucinactant is a lung surface acting agent, or "surfactant." It helps the lungs function normally. Lucinactant is similar to the natural fluid in the lungs that helps maintain effective breathing.
Lucinactant is used to treat or prevent respiratory distress syndrome (RDS) in a premature baby whose lungs have not fully developed.
Lucinactant may also be used for purposes not listed in this medication guide.
What is the most important information I should know about lucinactant?
Your baby will receive this medication in a neonatal intensive care unit (NICU) or similar hospital setting.
Lucinactant is given directly into the baby's lungs through a breathing tube that is also connected to a ventilator (a machine that moves air in and out of the lungs to help your baby breathe easier and get enough oxygen).
Your baby will remain under constant supervision during treatment with lucinactant.
What should I discuss with my healthcare provider before treatment with lucinactant?
To best participate in the care of your baby while he or she is in the NICU, carefully follow all instructions provided by your baby's caregivers.
How is lucinactant given?
Lucinactant is given directly into the baby's lungs through a breathing tube. Your baby will receive this medication in a neonatal intensive care unit (NICU) or similar hospital setting.
The breathing tube is connected to a ventilator (a machine that moves air in and out of the lungs to help your baby breathe easier and get enough oxygen).
Lucinactant is given as soon as possible after the baby's birth, usually within 30 minutes.
Your baby's breathing, blood pressure, oxygen levels, and other vital signs will be watched closely during treatment with lucinactant.
What happens if I miss a dose?
Since lucinactant is given as needed by a healthcare professional, it is not likely that your baby will miss a dose.
What happens if I overdose?
Since lucinactant is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. However, an overdose of lucinactant is not expected to produce life-threatening symptoms.
What should I avoid during treatment with lucinactant?
Follow your doctor's instructions about any restrictions in feeding, medications, or activity after your baby has been treated with lucinactant.
Lucinactant side effects
Lucinactant causes few side effects. There is a possibility that the baby will have breathing difficulties during the lucinactant treatment, and these problems may require further treatment by health care professionals. Your baby will remain under constant supervision during treatment with lucinactant.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Lucinactant dosing information
Usual Pediatric Dose for Respiratory Distress Syndrome:
Less than 48 hours of life:
-174 mg/kg (5.8 mL/kg) birth weight instilled intratracheally no more often than every 6 hours for a total of up to 4 doses in the first 48 hours of life.
48 hours of life or older:
-Data not available
-No information is available on doses greater than 5.8 mL per kg birth weight, the effects of more than 4 doses, or dosing more frequently than every 6 hours.
-Discontinue administration for bradycardia, oxygen desaturation, reflux of drug into the endotracheal tube (ETT), and airway/ETT obstruction. The clinical condition of the infant should be assessed and stabilized.
-Suctioning of the ETT or reintubation may be required if airway obstruction persists or is severe. After the patient is stable, dosing may proceed with appropriate monitoring.
Use: Prevention of respiratory distress syndrome (RDS) in premature infants at high risk for RDS
What other drugs will affect lucinactant?
Your baby's caregivers will manage and monitor all medications given to your baby during treatment in the NICU. A drug interaction between lucinactant and other medications is not expected to occur.
Do not give any medications to your baby that have not been prescribed by the baby's doctor. This includes vitamins, minerals, or herbal products.
Date modified: May 03, 2017
Last reviewed: August 14, 2012
More about lucinactant
- Other brands
Related treatment guides
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2021 Cerner Multum, Inc. Version: 1.02.