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Lotrel

Generic Name: amlodipine and benazepril (am LOE di peen and ben AY ze pril)
Brand Name: Lotrel

Medically reviewed on March 12, 2018.

What is amlodipine and benazepril?

Amlodipine is a calcium channel blocker. Amlodipine relaxes (widens) blood vessels and improves blood flow.

Benazepril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Benazepril also widens blood vessels and also prevents the body from retaining water.

Amlodipine and benazepril is a combination medicine used to treat high blood pressure (hypertension).

Amlodipine and benazepril may also be used for purposes not listed in this medication guide.

Important Information

Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.

You should not use this medicine if you have ever had angioedema. Do not take this medicine within 36 hours before or after taking medicine that contains sacubatril (such as Entresto).

If you have diabetes, do not use amlodipine and benazepril together with any medication that contains aliskiren (a blood pressure medicine).

Before taking this medicine

You should not use this medicine if you are allergic to amlodipine or benazepril, or if:

Do not take amlodipine and benazepril within 36 hours before or after taking medicine that contains sacubatril (such as Entresto).

If you have diabetes, do not use amlodipine and benazepril together with any medication that contains aliskiren (a blood pressure medicine).

You may also need to avoid taking amlodipine and benazepril with aliskiren if you have kidney disease.

Tell your doctor if you have ever had:

  • heart disease or congestive heart failure;

  • high levels of potassium in your blood (hyperkalemia);

  • kidney disease (or if you are on dialysis);

  • liver disease; or

  • if you are on a low-salt diet.

Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Benazepril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

You should not breast-feed while you are using this medicine.

How should I take amlodipine and benazepril?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take amlodipine and benazepril with or without food. Take the medicine at the same time each day.

Vomiting, diarrhea, or heavy sweating can cause you to become dehydrated. Drink plenty of water each day while you are taking this medicine.

Your blood pressure will need to be checked often, and you may also need frequent blood tests.

If you need surgery, tell your surgeon you currently use this medicine. You may need to stop for a short time.

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking amlodipine and benazepril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if you are more than 12 hours late for the dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking amlodipine and benazepril?

Drinking alcohol with this medicine can cause side effects.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Do not use salt substitutes or potassium supplements while taking amlodipine and benazepril, unless your doctor has told you to.

Amlodipine and benazepril side effects

Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.

Some side effects may not occur until after you have used the medicine for several months.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • swelling in your hands or feet, rapid weight gain;

  • new or worsened chest pain;

  • fever, chills, sore throat, body aches, flu symptoms;

  • high potassium--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; or

  • liver problems--nausea, stomach pain (upper right side), itching, unusual tiredness, flu-like symptoms, dark urine, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • cough;

  • dizziness; or

  • swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect amlodipine and benazepril?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines. Many drugs can affect amlodipine and benazepril, especially:

This list is not complete and many other drugs may affect amlodipine and benazepril. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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