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Lofibra

Generic Name: fenofibrate (FEN oh FYE brate)
Brand Name: Antara, Fenoglide, Lipofen, Lofibra, TriCor, Triglide

Medically reviewed on March 31, 2017

What is Lofibra?

Lofibra helps reduce cholesterol and triglycerides (fatty acids) in the blood. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries).

Lofibra may also be used for purposes not listed in this medication guide.

Important Information

You should not use Lofibra if you have liver disease, gallbladder disease, severe kidney disease, or if you are on dialysis.

Do not breast-feed while taking Lofibra.

Before taking this medicine

You should not use Lofibra if you are allergic to it, or if you have:

  • liver disease;

  • severe kidney disease (or if you are on dialysis);

  • gallbladder disease; or

  • if you are breast-feeding a baby.

To make sure Lofibra is safe for you, tell your doctor if you have:

  • kidney disease;

  • diabetes;

  • heart disease;

  • a thyroid disorder; or

  • a history of pancreatitis or liver disease.

It is not known whether Lofibra will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Fenofibrate can pass into breast milk and may harm a nursing baby. Do not breast-feed while taking fenofibrate.

How should I take Lofibra?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Some brands of fenofibrate should be taken with meals to help your body better absorb the medicine. Other brands may be taken with or without food. Follow the directions on your medicine label.

Use Lofibra regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Do not crush, break, or dissolve the Lofibra capsule or tablet. Swallow it whole.

If you also take cholestyramine, colesevelam, colestipol: these other medicines should be taken at least 1 hour after or 4 hours before you take Lofibra.

Lofibra is only part of a treatment program that may also include diet, exercise, and weight control. Follow your doctor's instructions very closely.

While using Lofibra, you may need frequent blood tests. Your liver and gallbladder function may also need to be checked.

Store at room temperature away from moisture, heat, and light. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Lofibra?

If you also take cholestyramine, colesevelam, or colestipol: Wait 4 to 6 hours after taking any of these other medicines before you take Lofibra. Avoid taking this medicine within 1 hour before taking the other medicine.

Avoid drinking alcohol. It can raise triglyceride levels, and may also damage your liver while you are taking Lofibra.

Lofibra side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

In rare cases, Lofibra can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Stop using Lofibra and call your doctor at once if you have:

  • severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;

  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

  • chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or

  • pain, swelling, warmth, or redness in one or both legs.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Lofibra?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Lofibra, especially:

This list is not complete. Other drugs may interact with fenofibrate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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