Medically reviewed on January 23, 2018
What is insulin lispro?
Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Insulin lispro is a fast-acting insulin that starts to work about 15 minutes after injection, peaks in about 1 hour, and keeps working for 2 to 4 hours.
Insulin lispro is used to improve blood sugar control in adults and children with diabetes mellitus.
Insulin lispro may also be used for purposes not listed in this medication guide.
Never share an injection pen, cartridge, or syringe with another person, even if the needle has been changed.
Before taking this medicine
Insulin lispro should not be given to a child younger than 3 years old. Insulin lispro should not be used to treat type 2 diabetes in a child of any age.
Tell your doctor if you have ever had:
liver or kidney disease; or
low levels of potassium in your blood (hypokalemia).
Tell your doctor if you also take medicine that contains pioglitazone or rosiglitazone. Taking certain oral diabetes medicines while you are using insulin may increase your risk of serious heart problems.
Follow your doctor's instructions about using insulin if you are pregnant or breast-feeding a baby. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester of pregnancy. Your dose needs may also be different while you are breast-feeding.
How should I use insulin lispro?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Insulin lispro is injected under the skin, or into a vein using an infusion pump. A healthcare provider will teach you how to properly use this medicine by yourself.
Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
Use this medicine within 15 minutes before a meal, or right after eating.
Concentrated insulin lispro (200 units) must not be given with an insulin pump, or mixed with other insulins.
Prepare your injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors or has particles in it. Call your pharmacist for new medicine.
Never share an injection pen, cartridge, or syringe with another person, even if the needle has been changed. Sharing these devices can allow infections or disease to pass from one person to another.
Use a needle and syringe only once and place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.
Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, and feeling anxious or shaky. To quickly treat low blood sugar, always keep a fast-acting source of sugar with you such as fruit juice, hard candy, crackers, raisins, or non-diet soda.
Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency.
Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination, blurred vision, headache, and tiredness.
Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your insulin dose or schedule.
Keep this medicine in its original container protected from heat and light. Do not freeze insulin or store it near the cooling element in a refrigerator. Throw away any insulin that has been frozen.
Storing unopened (not in use) insulin lispro:
Refrigerate and use until expiration date; or
Store at room temperature and use within 28 days.
Storing opened (in use) insulin lispro:
Store the vial in a refrigerator or at room temperature and use within 28 days.
Store the cartridge or injection pen (without a needle attached) at room temperature and use within 28 days.
What happens if I miss a dose?
Since insulin lispro is used before meals, you may not be on a timed dosing schedule. Whenever you use insulin lispro, be sure to eat a meal within 15 minutes. Do not use extra insulin lispro to make up a missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Insulin overdose can cause life-threatening hypoglycemia. Symptoms include drowsiness, confusion, blurred vision, numbness or tingling in your mouth, trouble speaking, muscle weakness, clumsy or jerky movements, seizure (convulsions), or loss of consciousness.
What should I avoid while using insulin lispro?
Insulin can cause low blood sugar. Avoid driving or operating machinery until you know how this medicine will affect you.
Avoid medication errors by always checking the medicine label before injecting your insulin.
Avoid drinking alcohol.
Insulin lispro side effects
Get emergency medical help if you have signs of insulin allergy: redness or swelling where an injection was given, itchy skin rash over the entire body, trouble breathing, fast heartbeats, feeling like you might pass out, or swelling in your tongue or throat.
Call your doctor at once if you have:
weight gain, swelling in your hands or feet, feeling short of breath; or
Common side effects may include:
low blood sugar;
itching, mild skin rash; or
thickening or hollowing of the skin where you injected the medicine.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect insulin lispro?
Many other medicines can affect your blood sugar, and some medicines can increase or decrease the effects of insulin. Some drugs can also cause you to have fewer symptoms of hypoglycemia, making it harder to tell when your blood sugar is low. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 7.01.
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