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Gocovri

Generic Name: amantadine (a MAN ta deen)
Brand Name: Gocovri, Osmolex ER

Medically reviewed on July 16, 2018

What is Gocovri?

Gocovri is a prescription medicine containing amantadine.

Gocovri is used to treat dyskinesia (sudden uncontrolled movements) in people with Parkinson's disease and "Parkinson-like" symptoms such as stiffness or tremors, shaking, and repetitive uncontrolled muscle movements that may be caused by the use of certain drugs.

Gocovri may also be used for purposes not listed in this medication guide.

Important Information

You should not use Gocovri if you received a nasal flu vaccine in the past 14 days.

Do not receive a nasal flu vaccine while taking Gocovri, and for at least 48 hours after your last dose.

Before taking this medicine

You should not use Gocovri if you are allergic to it, or if:

  • severe kidney disease; or

  • you have received a "live" nasal flu vaccine (FluMist) within the past 14 days.

Tell your doctor if you have ever had:

People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for.

It is not known whether Gocovri will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breast-feed while using this medicine.

Gocovri is not approved for influenza in a child younger than 1 year old. Gocovri is not approved for use by anyone younger than 18 years old.

How should I take Gocovri?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

If you take Gocovri to treat influenza A, start taking the medicine within 24 to 48 hours after flu symptoms begin. Keep taking this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared.

You may take Gocovri with or without food. You may need to take this medicine only at bedtime. Follow your doctor's instructions.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Swallow the capsule or tablet whole and do not crush, chew, or break it.

If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of applesauce. Swallow the mixture right away without chewing. Do not save it for later use.

Call your doctor if your symptoms do not improve, or if you have a fever with a headache, cough, skin rash, or other new symptoms.

If you take Gocovri for Parkinson symptoms: You should not stop using this medicine suddenly or your condition may become worse. Stopping suddenly may also cause unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

Call your doctor if you miss several doses in a row.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Gocovri can be fatal.

Overdose symptoms may include confusion, agitation, behavior changes, hallucinations, severe headache or pounding in your ears, muscle stiffness, problems with balance or walking, trouble breathing, fast heartbeats, or seizure.

What should I avoid while taking amantadine?

Do not receive a nasal flu vaccine while using Gocovri, and for at least 48 hours after your last dose. The vaccine may not work as well during this time, and may not fully protect you from disease.

Do not drink alcohol. Dangerous side effects could occur.

Avoid driving or operating machinery until you know how Gocovri will affect you. Gocovri may impair your thinking or reactions. Some people taking this medicine have fallen asleep during normal daytime activities such as working, talking, eating, or driving. You may fall asleep suddenly, even after feeling alert. Be careful if you drive or do anything that requires you to be alert.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with Gocovri can increase your risk of unpleasant side effects.

Gocovri side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • extreme drowsiness, falling asleep suddenly even after feeling alert;

  • a light-headed feeling, like you might pass out;

  • shortness of breath (even with mild exertion), swelling in your hands or feet;

  • painful or difficult urination;

  • depression, agitation, aggression, behavior changes, hallucinations, thoughts of hurting yourself;

  • a seizure; or

  • severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors.

You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs.

Side effects may be more likely in older adults.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Gocovri?

Using Gocovri with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect Gocovri, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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