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Generic Name: gadobutrol (GAD oh BUE trol)
Brand Name: Gadavist

Medically reviewed on January 2, 2018

What is gadobutrol?

Gadobutrol is a contrast agent that produces magnetic effects. It is used in combination with magnetic resonance imaging (MRI) or magnetic resonance angiography (MRA) to allow blood vessels, organs, and other non-bony tissues to be seen more clearly.

Gadobutrol is used to help diagnose certain disorders of the brain and spine (central nervous system), or the blood vessels of the kidneys. Gadobutrol is also used with MRI of the breast to help detect breast cancer.

Gadobutrol may also be used for purposes not listed in this medication guide.

Important Information

Gadobutrol can cause a life-threatening condition in people with advanced kidney disease. Before receiving this medicine, tell your doctor if you have kidney disease or if you are on dialysis. You may not be able to receive gadobutrol. Also tell your doctor if you have recently received any contrast agents similar to gadobutrol.

Before taking this medicine

Gadobutrol can cause a life-threatening condition in people with advanced kidney disease. You should not receive this medication if you have kidney disease or if you are on dialysis.

Gadobutrol can stay in your body for months or years after you receive this medicine. It is not known whether this could cause any health problems in people whose kidneys work properly. Tell your doctor if you have had repeated scans with a contrast agent, and provide the date of your last scan.

You should not receive gadobutrol if you are allergic to it.

To make sure gadobutrol is safe for you, tell your doctor if you have ever had:

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breast-feed within 18 hours after using gadobutrol. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.

How is gadobutrol given?

Gadobutrol is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting during your MRI or MRA.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when the medicine is injected.

Your doctor or other healthcare provider may want to watch you for a short time after your test is over. This is to make sure you do not have any unwanted side effects or delayed reactions.

What happens if I miss a dose?

Since gadobutrol is used only during your MRI or MRA, you will not be on a dosing schedule.

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving gadobutrol?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Gadobutrol side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects of gadobutrol may occur up to several days after injection.

Gadobutrol can cause a life-threatening condition in people with advanced kidney disease. Call your doctor right away if you have any symptoms of this condition, such as:

  • burning, itching, swelling, scaling, and tightening or hardening of your skin;

  • muscle weakness;

  • joint stiffness in your arms, hands, legs, or feet;

  • deep bone pain in your ribs or your hips;

  • trouble moving; or

  • skin redness or discoloration.

Also call your doctor at once if you have:

  • kidney problems--little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath; or

  • severe pain, burning, or irritation around the IV needle.

Common side effects may include:

  • headache;

  • feeling hot;

  • unusual or unpleasant taste in your mouth;

  • nausea; or

  • cold feeling, warmth, pain, or burning where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect gadobutrol?

Other drugs may interact with gadobutrol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.