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Exparel

Generic Name: bupivacaine liposome (bue PIV a kane LYE poe some)
Brand Name: Exparel

Medically reviewed on July 26, 2017.

What is bupivacaine liposome?

Bupivacaine is an anesthetic (numbing medicine) that blocks nerve impulses in your body.

Bupivacaine liposome is used as a local (in only one area) anesthetic to numb an area of your body for a minor surgery such as bunion removal or hemorrhoid surgery.

Bupivacaine may also be used for purposes not listed in this medication guide.

Important Information

Call your doctor if you have joint pain or stiffness, or weakness in any part of your body that occurs after your surgery, even months later.

Before taking this medicine

Tell your doctor if you have ever had an allergic reaction to any type of numbing medicine.

To make sure bupivacaine liposome is safe for you, tell your doctor if you have ever had:

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

Bupivacaine liposome can pass into breast milk, but effects on the nursing baby are not known. Tell your doctor if you are breast-feeding.

How is bupivacaine liposome given?

Bupivacaine is given as an injection placed into an area near your surgical incision. You will receive this injection in a hospital or surgical setting.

Bupivacaine liposome can have long-lasting or delayed effects. For at least 4 days (96 hours) after your surgery, tell any doctor or dentist who treats you that you recently received a bupivacaine liposome injection.

Call your doctor if you have joint pain or stiffness, or weakness in any part of your body that occurs after your surgery, even months later.

What happens if I miss a dose?

Since bupivacaine liposome is used as a single dose, it does not have a daily dosing schedule.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving bupivacaine liposome?

For at least 4 days (96 hours) after surgery, you may need to avoid using any pain or numbing medicines that contain lidocaine. This includes skin patches, sprays, creams, ointments, or gels applied to the skin. Follow your doctor's instructions.

Bupivacaine liposome side effects

Get emergency medical help if you have signs of an allergic reaction: hives, red rash, itching; sneezing, difficulty breathing; severe dizziness, vomiting; swelling of your face, lips, tongue, or throat.

You will be watched closely after receiving bupivacaine liposome, to make sure you do not have a reaction to the medicine. Tell your caregivers at once if you have any of these signs of a serious side effect:

  • ringing in your ears;

  • feeling restless or anxious;

  • feeling like you might pass out;

  • speech or vision problems, a metallic taste in your mouth;

  • numbness or tingling around your mouth;

  • tremors, twitching, mood changes;

  • fast heart rate, feeling short of breath, feeling unusually hot or cold;

  • numbness, weakness, or loss of movement where the injection was given; or

  • if you still feel numb several hours after your surgery.

Common side effects include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect bupivacaine liposome?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • topical (applied to the skin) medicine that contains lidocaine.

This list is not complete. Other drugs may interact with bupivacaine liposome, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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