Medically reviewed on December 14, 2017.
What is Estradiol Patch?
Estradiol is a form of estrogen, a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.
Estradiol Patch skin patches are used to treat certain symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. This medicine is also used to prevent postmenopausal osteoporosis, or to treat ovarian disorders.
Estradiol Patch may also be used for purposes not listed in this medication guide.
You should not use estradiol if you have: undiagnosed vaginal bleeding, liver disease, coronary artery disease, if you have major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.
Do not use if you are pregnant.
Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.
Using this medicine can increase your risk of blood clots, stroke, or heart attack. Estradiol should not be used to prevent heart disease, stroke, or dementia. Long-term use may increase your risk of cancer of the breast, uterus, or ovaries.
Before taking this medicine
You should not use estradiol if you are allergic to it, or if you have:
unusual vaginal bleeding that has not been checked by a doctor;
coronary artery disease;
a history of heart attack, stroke, or blood clot; or
a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.
Do not use estradiol if you are pregnant. Tell your doctor right away if you become pregnant during treatment.
Using estradiol can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.
Estradiol should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions.
To make sure estradiol is safe for you, tell your doctor if you have ever had:
a thyroid disorder;
epilepsy or other seizure disorder;
porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);
endometriosis or uterine fibroid tumors;
high levels of calcium in your blood; or
hereditary angioedema (an immune system disorder).
Long-term use of estradiol may increase your risk of cancer of the breast, uterus, or ovaries. Talk with your doctor about this risk.
Estradiol lowers the hormone needed to produce breast milk and can slow breast milk production. Tell your doctor if you are breast-feeding.
How should I use Estradiol Patch?
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
Apply the skin patch to clean, dry skin on your stomach or buttocks. Press the patch firmly into place for at least 10 seconds. Choose a different spot within these skin areas each time you apply a new patch. Do not use the same skin area twice within 7 days. Avoid skin that is irritated or damaged.
Do not apply a skin patch to your breasts. Do not apply a patch where it might be rubbed off by tight clothing, such as under an elastic waistband. Never cut a skin patch.
If a patch falls off, try sticking it back into place. If it does not stick well, put on a new patch on a different skin area and leave it on only for the rest of your wearing time. Do not change your patch removal schedule.
Remove the patch and replace it with a new patch 2 times per week. Change your patch on the same 2 days each week to stay on schedule.
Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin to help lower this risk. Report any unusual vaginal bleeding right away.
If you need major surgery with long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using estradiol.
Your doctor should check your progress on a regular basis to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis, and have regular mammograms while using Estradiol Patch.
Store patches at room temperature away from moisture and heat. Keep each patch in its pouch until you are ready to use it.
After removing a skin patch, fold it in half so it sticks together. Discard the folded patch in a place children and pets cannot get to.
What happens if I miss a dose?
Apply a skin patch as soon as you remember. Skip the missed dose if it is almost time for your next scheduled patch change. Do not use extra patches to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using Estradiol Patch?
Avoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while using estradiol.
Avoid using creams, lotions, or powders on the skin where you apply the patch, or it may not stick to your skin.
Estradiol Patch side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Remove the skin patch and call your doctor at once if you have:
heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;
swelling or tenderness in your stomach;
jaundice (yellowing of the skin or eyes);
unusual vaginal bleeding, pelvic pain;
a breast lump;
memory problems, confusion, unusual behavior; or
Common side effects may include:
vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding;
bloating, stomach cramps, nausea, vomiting;
redness or irritation where the patch was worn;
thinning scalp hair; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Estradiol Patch?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Other drugs may interact with estradiol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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More about Estradiol Patch (estradiol)
- Estradiol Patch Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 16 Reviews – Add your own review/rating
- Drug class: estrogens