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EmGyn Kit (injection)

Generic name: methotrexate (injection) [ meth-oh-TREX-ate ]
Brand names: EmGyn Kit, Methotrexate Sodium, Preservative Free, Otrexup, Rasuvo
Drug classes: Antimetabolites, Antipsoriatics, Antirheumatics, Other immunosuppressants

Medically reviewed by on Jun 8, 2022. Written by Cerner Multum.

What is EmGyn Kit?

EmGyn Kit is used to treat leukemia and certain types of cancer of the breast, bones, skin, head and neck, or lung.

EmGyn Kit is also used to treat severe psoriasis and rheumatoid arthritis in adults, and to treat active polyarticular-course juvenile rheumatoid arthritis in children.

EmGyn Kit is often used when other medicines have not been effective.

EmGyn Kit may also be used for purposes not listed in this medication guide.


EmGyn Kit should not be used during pregnancy to treat arthritis or psoriasis. This medicine is sometimes used to treat cancer during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant.

Do not use EmGyn Kit to treat psoriasis or rheumatoid arthritis if you have low blood cell counts, a weak immune system, alcoholism or chronic liver disease, or if you are pregnant or breastfeeding.

EmGyn Kit can cause serious or fatal side effects. Tell your doctor if you have diarrhea, mouth sores, cough, shortness of breath, upper stomach pain, dark urine, numbness or tingling, muscle weakness, confusion, seizure, or skin rash that spreads and causes blistering and peeling.

Before taking this medicine

You should not use EmGyn Kit if you are allergic to it. This medicine should not be used to treat psoriasis or rheumatoid arthritis if you have:

  • alcoholism, cirrhosis, or chronic liver disease;

  • low blood cell counts, o a weak immune system or bone marrow disorder; or

  • if you are pregnant or breastfeeding.

EmGyn Kit is sometimes used to treat cancer in people who have a condition listed above. Your doctor will decide if this treatment is right for you.

Tell your doctor if you have ever had:

EmGyn Kit is sometimes used to treat cancer during pregnancy. However, this medicine may cause injury or death to an unborn baby and should not be used during pregnancy to treat arthritis or psoriasis. Tell your doctor if you are pregnant.

EmGyn Kit can harm an unborn baby if the mother or the father is using EmGyn Kit.

  • If you are a woman, you may need a pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using EmGyn Kit and for at least 6 months after your last dose.

  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.

  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using EmGyn Kit.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because EmGyn Kit may harm the baby if a pregnancy does occur.

Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

Do not give this medicine to a child without medical advice.

How is EmGyn Kit given?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

EmGyn Kit is usually given once per week. You must use the correct dose. Some people have died after incorrectly using this medicine every day.

EmGyn Kit is injected into a muscle, under the skin, or as an infusion into a vein. A healthcare provider will give you this injection and may teach you how to properly use the medication by yourself.

EmGyn Kit may also be injected by a healthcare provider directly into a joint, or into the space around your spinal cord.

Read and carefully follow any Instructions for Use provided with your medicine. You may need to mix EmGyn Kit with a liquid (diluent) before using it. Ask your doctor or pharmacist if you don't understand all instructions.

Prepare an injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

EmGyn Kit can be toxic to your organs, and may lower your blood cell counts. You will need frequent medical tests, and you may need an occasional liver biopsy or chest X-ray.

If you develop a new (secondary) cancer during treatment with EmGyn Kit, your healthcare provider will stop this medicine, and provide treatment if the new cancer does not go away after this medicine is stopped.

If you need to be sedated for dental work, tell your dentist you currently use EmGyn Kit.

Follow all storage instructions provided with your injectable medication. Your healthcare provider can provide more information about how to store this medicine.

A single-use vial (bottle) or auto-injector is for one use only. Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your EmGyn Kit, or if you forget to use the medicine at home.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of methotrexate injection can be fatal.

What should I avoid while receiving EmGyn Kit?

Avoid exposure to sunlight or artificial UV rays (sunlamps, tanning beds, or PUVA treatment), especially if you have psoriasis. EmGyn Kit can make your skin more sensitive to sunlight and your psoriasis may worsen.

Avoid drinking alcohol. It may increase your risk of liver damage.

Do not receive a "live" vaccine while using EmGyn Kit, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

EmGyn Kit may impair your thinking or reactions. Avoid driving or operating machinery until you know how EmGyn Kit will affect you.

EmGyn Kit side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

EmGyn Kit can cause serious or fatal side effects. Call your doctor at once if you have:

  • sudden chest pain, wheezing, dry cough, cough with mucus, feeling short of breath;

  • swollen lymph glands, night sweats, weight loss;

  • blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;

  • vomiting, diarrhea, blood in your urine or stools;

  • skin changes such as redness, warmth, swelling, or oozing;

  • signs of metabolic acidosis--confusion, vomiting, lack of energy, irregular heartbeats;

  • low blood cell counts--fever, chills, bruising or bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath;

  • kidney problems--little or no urination, swelling in your feet or ankles;

  • liver problems--swelling around your midsection, right-sided upper stomach pain, nausea, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes);

  • nerve problems--confusion, weakness, drowsiness, coordination problems, feeling irritable, headache, neck stiffness, vision problems, loss of movement in any part of your body, seizure; or

  • signs of tumor cell breakdown--tiredness, muscle cramps, nausea, vomiting, diarrhea, fast or slow heart rate, tingling in your hands and feet or around your mouth.

Common side effects of EmGyn Kit may include:

  • low blood cell counts, fever, chills, tiredness, not feeling well;

  • headache, dizziness, cough, chest tightness, trouble breathing;

  • mouth sores, nausea, vomiting, stomach pain, indigestion, diarrhea;

  • abnormal liver function tests;

  • runny or stuffy nose, sore throat; or

  • rash, hair loss, burning skin lesions, being more sensitive to light.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect EmGyn Kit?

EmGyn Kit can harm your liver, especially if you also use certain medicines for infections, tuberculosis, birth control, hormone replacement, high cholesterol, heart problems, high blood pressure, seizures, pain, or arthritis (including Tylenol, Advil, Motrin, or Aleve).

Tell your doctor about all your other medicines, especially:

This list is not complete and many other drugs may affect EmGyn Kit. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Popular FAQ

Methotrexate is a medicine that is commonly prescribed for people with rheumatoid arthritis, psoriasis, or cancer, and it can lower levels of folate (a B vitamin) in your body. You should take folic acid with methotrexate to help prevent a folate deficiency. A folate deficiency can lead to symptoms like tiredness, muscle weakness, mouth sores, and neurological symptoms. Continue reading

To tell if methotrexate treatment is working for your rheumatoid arthritis your doctor will conduct regular blood tests and check-ups. You can also keep a track of your symptoms and looks for signs of improvement. Imaging tests, such as x-rays and musculoskeletal ultrasound (MSUS), may be used. Continue reading

​Methotrexate was shown to cause a modest amount of weight gain over 6 months, in a study measuring weight changes in people with rheumatoid arthritis. Continue reading

Methotrexate can start working for rheumatoid arthritis within 3 to 6 weeks and symptoms continue to improve over 3 months. For other people it might take a few months before they notice any improvement in their rheumatoid arthritis symptoms. Continue reading

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.