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Generic Name: taliglucerase alfa (TAL i GLOO ser ase AL fa)
Brand Name: Elelyso

Medically reviewed on January 4, 2017

What is taliglucerase alfa?

Taliglucerase is a man-made form of an enzyme that occurs naturally in the body. It is used as an enzyme replacement in people with Type I Gaucher disease.

Gaucher disease is a genetic condition in which the body lacks the enzyme needed to break down certain fatty materials (lipids). Lipids can build up in the body, causing symptoms such as easy bruising or bleeding, weakness, anemia, bone or joint pain, enlarged liver or spleen, or weakened bones that are easily fractured.

Taliglucerase may improve the condition of the liver, spleen, bones, and blood cells in people with Type I Gaucher disease. However, taliglucerase is not a cure for this condition.

Taliglucerase may also be used for purposes not listed in this medication guide.

Important Information

Some people receiving a taliglucerase alfa injection have had a reaction when the medicine was injected, or up to 3 hours later. Tell your caregivers right away if you have a sudden headache, dizziness, warmth or tingling, chest pain, wheezing, nausea, or a red skin rash.

Before taking this medicine

You should not use taliglucerase alfa if you are allergic to it.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether taliglucerase alfa passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How is taliglucerase alfa given?

Taliglucerase alfa is injected into a vein through an IV. A healthcare provider will give you this injection.

You may be given other medications to prevent certain side effects of taliglucerase alfa.

Taliglucerase alfa is usually given every other week. Follow your doctor's dosing instructions very carefully.

Your doctor may occasionally change your dose to make sure you get the best results.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your taliglucerase alfa injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking taliglucerase alfa?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Taliglucerase alfa side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; blue lips or fingernails; swelling of your face, lips, tongue, or throat.

Some people receiving a taliglucerase alfa injection have had a reaction when the medicine was injected, or up to 3 hours later. Tell your caregivers right away if you have:

  • dizziness, anxiety, weakness, tired feeling;

  • sudden headache, or light-headed feeling (like you might pass out);

  • flushing (warmth, redness, or tingly feeling);

  • fast or uneven heartbeats, chest pain or tightness, wheezing;

  • nausea, vomiting; or

  • red skin rash.

Common side effects may include:

  • headache;

  • rash, itching, warmth or tingly feeling;

  • dizziness or tired feeling;

  • nausea, stomach pain, vomiting; or

  • joint pain, back pain, pain in your arms or legs.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect taliglucerase alfa?

Other drugs may interact with taliglucerase alfa, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.