Medically reviewed on October 2, 2017.
What is allopurinol and lesinurad?
Allopurinol reduces the production of uric acid in your body. Uric acid buildup can lead to gout.
Lesinurad helps the kidneys remove uric acid from the body.
Allopurinol and lesinurad is a combination medicine used to reduce blood levels of uric acid in adults with gout.
This medicine is usually given when taking allopurinol alone has not been effective.
Allopurinol and lesinurad may also be used for purposes not listed in this medication guide.
Allopurinol and lesinurad can cause kidney failure. Call your doctor right away if you urinate less than usual or not at all, or if you have lower back pain, swelling in your feet or ankles, or shortness of breath.
Stop taking this medicine and get emergency medical help if you have signs of a severe skin reaction, such as a painful, itchy, or blistering skin rash. You may also have a fever, swollen glands, or joint pain.
Before taking this medicine
You should not use this medicine if you are allergic to allopurinol or lesinurad, or if you have:
severe kidney disease (or if you are on dialysis);
tumor lysis syndrome (fast breakdown of tumor cells);
Lesch-Nyhan syndrome; or
if you have received a kidney transplant.
To make sure allopurinol and lesinurad is safe for you, tell your doctor if you have ever had:
heart disease; or
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Other forms of hormonal contraception (injections, implants, skin patches, vaginal rings, and certain intrauterine devices) may not be effective enough to prevent pregnancy during your treatment with allopurinol and lesinurad.
It is not known whether allopurinol and lesinurad passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.
How should I take allopurinol and lesinurad?
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
The usual dose of this medicine is 1 tablet every morning.
Take this medicine with food and a full glass of water.
Drink at least 2 liters (68 ounces) of liquids every day to keep your kidneys working properly.
You may need medical tests to check your kidney function before and during treatment with this medicine. Your blood cells may also need to be tested often.
Gout symptoms may get worse when you first start taking allopurinol and lesinurad. Even if you have a gout flare-up, keep using the medication as directed.
Call your doctor if your gout symptoms do not eventually improve.
You should not take this medicine together with Zurampic (single-ingredient lesinurad) or you could get an overdose of lesinurad.
Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Skip the missed dose and take the next regularly scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking allopurinol and lesinurad?
This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Allopurinol and lesinurad side effects
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Call your doctor at once if you have:
a painful, itchy, or blistering skin rash (especially if you also have a fever, swollen glands, or joint pain);
kidney problems--pain in your side or lower back, nausea, vomiting, little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
liver problems--loss of appetite, upper stomach pain (right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
heart problems--chest pain or pressure, pain spreading to your jaw or shoulder; or
signs of a blood clot--sudden numbness or weakness, problems with vision or speech, swelling or redness in an arm or leg.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect allopurinol and lesinurad?
Many drugs can interact with allopurinol and lesinurad. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:
an antibiotic or antifungal medicine;
heart or blood pressure medication;
hormonal birth control (pills, patches, implants, or certain intrauterine devices); or
other gout medications.
This list is not complete and many other drugs can interact with allopurinol and lesinurad. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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- Drug class: antihyperuricemic agents