Duragesic-25 (skin patch)
Generic Name: fentanyl transdermal (skin patch) (FEN ta nil trans DERM al)
Brand Name: Duragesic-100, Duragesic-12, Duragesic-25, Duragesic-50, Duragesic-75
What is Duragesic-25 (fentanyl transdermal skin patch)?
Fentanyl is an opioid pain medication. An opioid is sometimes called a narcotic.
The fentanyl skin patch is used to treat moderate to severe chronic pain around the clock. Fentanyl transdermal is not for treating mild or occasional pain or pain from surgery.
Fentanyl transdermal may also be used for purposes not listed in this medication guide.
What is the most important information I should know about a this medicine?
Fentanyl can slow or stop your breathing. MISUSE OF FENTANYL TRANSDERMAL CAN CAUSE DEATH, especially in a child who gets a hold of the skin patch and places it in the mouth or on the skin.
Fentanyl may be habit-forming. Never share this medicine with another person, especially someone with a history of drug abuse or addiction.
Do not use a fentanyl skin patch if you have a breathing problem, a blockage in your stomach or intestines, or if you are NOT already being treated with a similar opioid (narcotic) pain medicine and are tolerant to it. Do not use a heating pad or other source of heat while you are wearing the patch.
What should I discuss with my healthcare provider before using a Duragesic-25 (fentanyl transdermal skin patch)?
Do not use a fentanyl skin patch if you are allergic to fentanyl, or if you have:
a severe breathing problem such as asthma attacks;
a blockage in your digestive tract (stomach or intestines); or
if you are NOT already being treated with a similar opioid (narcotic) pain medicine and are tolerant to it.
Some medicines can interact with fentanyl and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.
To make sure fentanyl transdermal is safe for you, tell your doctor if you have:
any type of breathing problem or lung disease;
a history of head injury, brain tumor, mental illness, alcoholism or drug addiction;
liver or kidney disease;
problems with your gallbladder, pancreas, or thyroid; or
if you use a sedative like Valium (diazepam, alprazolam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Versed, Xanax, and others).
Do not put a fentanyl skin patch on any child who does not have a personal prescription for this medicine.
If you use fentanyl while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.
Fentanyl can pass into breast milk and may cause withdrawal symptoms in a nursing infant. Do not breast-feed while using fentanyl transdermal.
The fentanyl skin patch may burn your skin if you wear the patch during an MRI (magnetic resonance imaging). Remove the patch before undergoing such a test.
How should I use Duragesic-25 (fentanyl transdermal skin patch)es?
Follow all directions on your prescription label. Never use fentanyl in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in relieving your pain. Do not use a skin patch if it has been cut or damaged, or you could receive a fatal overdose of fentanyl.
Fentanyl may be habit-forming, and the transdermal skin patch contains a high concentration of this medicine. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away fentanyl is against the law.
MISUSE OF FENTANYL TRANSDERMAL CAN CAUSE HARMFUL SIDE EFFECTS OR DEATH, especially in a child who gets a hold of the skin patch and places it in the mouth or on the skin.
When placing a skin patch on a young child, choose a wearing area where the child cannot easily remove the patch unsupervised.
Do not take by mouth. A fentanyl skin patch is for use only on the skin. Avoid touching the sticky side of a skin patch.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
Avoid sources of heat while you are wearing the patch. Do not use a heating pad or electric blanket, a waterbed heater, tanning bed or sauna. Do not sit in hot water, sunbathe, or raise your body temperature with vigorous activity. Heat can increase the amount of drug you absorb through your skin and may cause an overdose or death.
Remove and replace the patch every 72 hours. Apply the new patch to a different skin area on the chest, back, side, or upper arm. After removing a skin patch: fold it in half with the sticky side in, and flush the patch down the toilet right away. Do not place a used skin patch into a trash can.
Keep fentanyl skin patches out of the reach of children or pets. The amount of fentanyl in a new or used patch could be fatal to a child or pet who accidentally chews, sucks on, or swallows the patch. Seek emergency medical attention if this happens.
Store the skin patches at room temperature. Keep each patch in its foil pouch until you are ready to use it. Keep track of how many skin patches have been used from each new package. Fentanyl is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.
If you have leftover patches, ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused patches in the same folded manner described above.
What happens if I miss a dose?
If you are using the skin patches on a schedule, apply the missed patch as soon as you remember. Continue wearing the patch for up to 72 hours and then apply a new one if needed for pain. Do not wear extra patches to make up a missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A fentanyl overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include slow breathing and heart rate, severe drowsiness, muscle weakness, cold and clammy skin, pinpoint pupils, and fainting.
What should I avoid while using a Duragesic-25 (fentanyl transdermal skin patch) patch?
This medication may impair your thinking or reactions. Do not drive or operate machinery until you know how fentanyl will affect you. Dizziness or severe drowsiness can cause falls or other accidents.
Do not drink alcohol or dangerous side effects and death could occur. Check your food and medicine labels to be sure these products do not contain alcohol.
Avoid wearing a skin patch on a part of your body where a child could reach or remove the patch from your skin. Avoid allowing children to watch you put on a skin patch. Never tell a child that the fentanyl skin patch is a "bandage."
A Duragesic-25 (fentanyl transdermal skin patch) side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Like other narcotic medicines, fentanyl can slow your breathing. Death may occur if breathing becomes too weak.
Remove the skin patch and call your doctor at once if you have:
slow heart rate, sighing, weak or shallow breathing (up to several days after removing the skin patch);
chest pain, fast or pounding heartbeats; or
extreme drowsiness, feeling like you might pass out.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Common side effects may include:
nausea, vomiting, stomach pain, loss of appetite, diarrhea, constipation;
drowsiness, dizziness, tired feeling;
sleep problems (insomnia); or
increased sweating, or cold feeling.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Duragesic-25 (fentanyl transdermal skin patch)?
Some drugs can raise or lower your blood levels of fentanyl, which may cause side effects or make fentanyl less effective. Tell your doctor if you also use certain antibiotics, antifungal medications, heart or blood pressure medications, or medicines to treat HIV or AIDS.
Fentanyl can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:
other narcotic medications--opioid pain medicine or prescription cough medicine;
drugs that make you sleepy or slow your breathing--a sleeping pill, muscle relaxer, sedative, tranquilizer, or antipsychotic medicine; or
drugs that affect serotonin levels in your body--medicine for depression, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting.
This list is not complete. Other drugs may interact with fentanyl, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More about Duragesic-25 (fentanyl)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 4 Reviews – Add your own review/rating
- Generic Availability
- Drug class: narcotic analgesics
Related treatment guides
Where can I get more information?
- Your doctor or pharmacist can provide more information about fentanyl transdermal.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 10.07.
Date modified: March 15, 2017
Last reviewed: September 30, 2016