Medically reviewed on January 9, 2018.
What is bazedoxifene and conjugated estrogens?
Bazedoxifene blocks estrogen from reaching certain cells in the uterine lining, to protect against overgrowth of uterine tissue.
Bazedoxifene and conjugated estrogens is a combination medicine used short-term in women after menopause to treat moderate to severe hot flashes, and to prevent osteoporosis. This medicine is used in women who have NOT had a hysterectomy (uterus removed).
Conjugated estrogens should not be used to prevent heart disease, strokes, or dementia, because this medicine may actually increase your risk of developing these conditions.
Bazedoxifene and conjugated estrogens may also be used for purposes not listed in this medication guide.
Do not take any other estrogens while you are taking bazedoxifene and conjugated estrogens.
You should not use this medicine if you have any of the following conditions: a history of heart attack, stroke, or blood clot; liver disease; abnormal vaginal bleeding; a hormone-related cancer such as breast or uterine cancer.
This medicine may increase your risk of developing cancer of the breast or uterus, and may also increase your risk of dementia, heart attack, stroke, or blood clot. Ask your doctor about your individual risk.
Bazedoxifene and conjugated estrogens is for short-term use at the lowest dose needed to treat your condition.
Before taking this medicine
You should not use this medicine if you are allergic to bazedoxifene or conjugated estrogens (Premarin), or if you have:
a history of heart attack, stroke, or blood clot (especially in your lung or your lower body);
abnormal vaginal bleeding that a doctor has not checked;
a bleeding or blood-clotting disorder;
liver disease; or
any type of breast, uterine, or hormone-dependent cancer.
Women who are 75 or older should not take bazedoxifene and conjugated estrogens.
To make sure bazedoxifene and conjugated estrogens is safe for you, tell your doctor if you have:
high blood pressure, heart disease, or circulation problems;
vision problems, or circulation problems in the blood vessels of your eyes;
a problem with your thyroid or gallbladder;
asthma or other breathing problems;
epilepsy or other seizure disorder;
systemic lupus erythematosus (SLE);
high levels of calcium in your blood;
if you use hormone medications to treat cancer of the breast, ovary, or uterus.
This medicine may increase your risk of developing cancer of the breast or uterus. Your risk of uterine cancer may be greater if you are overweight. This medicine may also increase your risk of dementia, heart attack, stroke, or blood clot. Ask your doctor about your individual risk.
FDA pregnancy category X. This medication can harm an unborn baby or cause birth defects. Do not use bazedoxifene and conjugated estrogens if you are pregnant. Tell your doctor right away if you become pregnant during treatment.
It is not known whether bazedoxifene and conjugated estrogens passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
How should I take bazedoxifene and conjugated estrogens?
This medicine is usually taken once daily. Follow all directions on your prescription label. Bazedoxifene and conjugated estrogens is for short-term use at the lowest dose needed to treat your condition. Do not take this medicine in larger or smaller amounts or for longer than recommended.
You may take bazedoxifene and conjugated estrogens with or without food. Take the medicine at the same time each day.
Do not crush, chew, or break the tablet. Swallow it whole.
Your doctor should check your progress on a regular basis to determine whether you should continue this treatment.
Have regular physical exams and mammograms, and self-examine your breasts for lumps on a monthly basis while using this medicine.
If you need surgery or medical tests or if you will be on bed rest, you may need to stop using this medication for a short time. Any doctor or surgeon who treats you should know that you are taking bazedoxifene and conjugated estrogens.
Your doctor may have you take extra calcium and vitamin D while you are taking bazedoxifene and conjugated estrogens. Take only the amount that your doctor has prescribed.
Store at room temperature away from moisture and heat. Keep each tablet in its blister pack until you are ready to take it. Do not use a pill box for this medicine.
Write down the date you open a Duavee foil pouch. After opening the pouch, you should use the medicine within 60 days.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking bazedoxifene and conjugated estrogens?
Do not take progestins or any other estrogen while you are taking bazedoxifene and conjugated estrogens.
Bazedoxifene and conjugated estrogens side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using bazedoxifene and conjugated estrogens and call your doctor at once if you have:
sudden vision loss;
a lump in your breast;
signs of a blood clot in your leg--pain, swelling, warmth, or redness in one or both legs;
heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; or
liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Common side effects may include:
nausea, stomach pain or discomfort, diarrhea;
neck pain, muscle spasm; or
throat or sinus pain.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect bazedoxifene and conjugated estrogens?
Other drugs may interact with bazedoxifene and conjugated estrogens, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 1.01.
More about Duavee (bazedoxifene / conjugated estrogens)
- Duavee Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
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- En Español
- 11 Reviews – Add your own review/rating
- Drug class: sex hormone combinations