Skip to Content

B & O Supprettes 16-A (rectal)

Generic Name: belladonna and opium (rectal) (BEL a DON a and OH pee um)
Brand Name: B & O Supprettes 15-A, B & O Supprettes 16-A

Medically reviewed by on Dec 1, 2020 – Written by Cerner Multum

What is B & O Supprettes 16-A?

Belladonna is a natural substance made from a toxic plant. The medicinal form of belladonna has many effects in the body, such as decreasing muscle activity.

Opium is also a natural substance made from the seeds of a plant. The medicinal form of opium is an opioid pain medication, sometimes called a narcotic.

B & O Supprettes 16-A is a combination medicine used to treat moderate to severe pain caused by muscle spasms in the tubes that connect the kidneys to the bladder.

B & O Supprettes 16-A may also be used for purposes not listed in this medication guide.

Important Information

You should not use B & O Supprettes 16-A if you have glaucoma, severe breathing problems, severe liver or kidney disease, seizures, or if you have recently used drugs or alcohol.

B & O Supprettes 16-A may be habit-forming. Misuse of habit-forming medicine can cause addiction, overdose, or death.

Before taking this medicine

Do not use B & O Supprettes 16-A if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

You should not use B & O Supprettes 16-A if you are allergic to belladonna or opium, or if you have:

  • severe asthma or breathing problems;

  • seizures;

  • glaucoma;

  • severe liver or kidney disease;

  • a blockage in your stomach or intestines; or

  • if you drank alcohol within the past few hours.

To make sure B & O Supprettes 16-A is safe for you, tell your doctor if you have ever had:

If you use opium while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether belladonna and opium passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

How should I use B & O Supprettes 16-A rectal?

Follow all directions on your prescription label. Never use B & O Supprettes 16-A in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Opium may be habit-forming, even at regular doses. Never share the medicine with another person. MISUSE OF NARCOTIC PAIN MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Selling or giving away this medicine is against the law.

Do not take a rectal suppository by mouth. It is for use only in your rectum.

Wash your hands before and after inserting the rectal suppository.

Try to empty your bowel and bladder just before using the B & O Supprettes 16-A suppository.

Remove the wrapper before inserting the suppository. Avoid handling the suppository too long or it will melt in your hands.

Lie on your back with your knees up toward your chest. Gently insert the suppository into your rectum about 1 inch, pointed tip first.

For best results, stay lying down for a few minutes. The suppository will melt quickly and you should feel little or no discomfort while holding it in. Avoid using the bathroom for at least an hour after using the suppository.

Drink plenty of water to prevent constipation while using B & O Supprettes 16-A.

B & O Supprettes 16-A is most often used 1 or 2 times per day. Do not use the suppositories more than 4 times per day. Follow your doctor's instructions. Call your doctor if your symptoms do not improve, or if they get worse while using this medication.

Do not stop using B & O Supprettes 16-A suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using this medicine.

Store at room temperature away from moisture, heat, and light. Do not refrigerate or freeze the suppositories.

Keep track of your medicine. B & O Supprettes 16-A is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.

What happens if I miss a dose?

Since B & O Supprettes 16-A is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A B & O Supprettes 16-A overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include slow breathing, severe drowsiness, pinpoint pupils, and coma.

What should I avoid while using B & O Supprettes 16-A?

This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how B & O Supprettes 16-A will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

Avoid becoming overheated or dehydrated during exercise and in hot weather. This medication can decrease sweating and you may be more prone to heat stroke.

Drinking alcohol can increase certain side effects of belladonna and opium.

B & O Supprettes 16-A side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • weak or shallow breathing;

  • a light-headed feeling, like you might pass out;

  • fast heartbeats;

  • painful or difficult urination;

  • little or no urination; or

  • severe constipation and stomach pain.

Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.

Common side effects may include:

  • drowsiness, dizziness;

  • blurred vision;

  • constipation;

  • itching or rash;

  • dry mouth; or

  • increased sensitivity to light.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect B & O Supprettes 16-A?

Using B & O Supprettes 16-A with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before taking a sleeping pill, an opioid medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Other drugs may interact with belladonna and opium, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.