Generic Name: dolasetron (injection) (doe LAY se tron)
Brand Name: Anzemet
What is dolasetron?
Dolasetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.
Dolasetron injection is used to prevent nausea and vomiting caused by surgery.
Dolasetron injection may also be used for purposes not listed in this medication guide.
What is the most important information I should know about dolasetron injection?
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
What should I discuss with my healthcare provider before receiving dolasetron injection?
You should not receive dolasetron if you are allergic to it.
Dolasetron can cause serious heart rhythm problems. You should not use this medicine if you have a history of Long QT syndrome. Tell your doctor if anyone in your family has ever had this condition.
To make sure dolasetron is safe for you, tell your doctor if you have:
a serious heart condition such as "sick sinus syndrome";
a heart rhythm disorder such as slow heartbeats, or atrial fibrillation (fast, irregular heart rhythm);
congestive heart failure; or
an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).
FDA pregnancy category B. Dolasetron is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether dolasetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How is dolasetron injection given?
For adults, dolasetron is injected into a vein through an IV. For children, the medicine may be mixed with apple juice and given orally (by mouth). You will receive this injection in a clinic or hospital setting before or during surgery.
In most cases, only one dose of dolasetron is given while you are still under anesthesia, or as soon as you have symptoms of nausea or vomiting.
Dolasetron injection is not for preventing nausea or vomiting that is caused by chemotherapy or factors other than surgery.
What happens if I miss a dose?
Since dolasetron injection is usually given as single dose by a healthcare professional, you will not be on a frequent dosing schedule.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include depression, tremors, feeling light-headed, fainting, or seizure (convulsions).
What should I avoid after receiving dolasetron injection?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Dolasetron injection side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have:
headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
a light-headed feeling, like you might pass out;
slow heart rate, weak pulse, slow breathing;
little or no urinating; or
high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.
Common side effects may include:
fast or slow heart rate;
chills, shivering, anxiety;
upset stomach, diarrhea;
tired feeling; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect dolasetron injection?
There are many other medicines that can increase your risk of heart rhythm problems if you use them together with dolasetron.
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with dolasetron, especially:
an antibiotic--azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, pentamidine;
cancer medicine--arsenic trioxide, vandetanib;
an antidepressant--citalopram, escitalopram;
anti-malaria medication--chloroquine, halofantrine;
heart rhythm medicine--amiodarone, disopyramide, dofetilide, dronedarone, flecainide, ibutilide, quinidine, sotalol; or
medicine to treat a psychiatric disorder--chlorpromazine, haloperidol, pimozide, thioridazine.
This list is not complete. Other drugs may interact with dolasetron, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More about Anzemet (dolasetron)
Related treatment guides
Where can I get more information?
- Your doctor or pharmacist can provide more information about dolasetron injection.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 3.01.
Last reviewed: October 28, 2014
Date modified: October 14, 2016