Generic Name: dalfampridine (dal FAM pri deen)
Brand Name: Ampyra
Medically reviewed on February 14, 2017.
What is dalfampridine?
Dalfampridine is a potassium channel blocker.
Dalfampridine is used to improve walking in patients with multiple sclerosis (MS).
Dalfampridine may also be used for purposes not listed in this medication guide.
Dalfampridine can cause a seizure (convulsions), even if you have never had one before. Taking too much dalfampridine may increase your risk of seizure. Kidney problems may also increase your risk. Your kidney function may need to be tested before you start taking this medicine.
You should not use dalfampridine if you have moderate to severe kidney disease, or if you have ever had a seizure (convulsions).
Stop taking dalfampridine and call your doctor right away if you have a seizure.
Before taking this medicine
You should not use dalfampridine if you are allergic to it, or if:
you have had a seizure (convulsions); or
you have moderate to severe kidney disease.
To make sure dalfampridine is safe for you, tell your doctor if you have:
kidney disease; or
if you also take a form of this medicine obtained from a compounding pharmacy (fampridine, or 4-aminopyridine).
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether dalfampridine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
Dalfampridine is not approved for use by anyone younger than 18 years old.
How should I take dalfampridine?
Before you start treatment with dalfampridine, your doctor may perform tests to check your kidney function.
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. High doses of dalfampridine may increase your risk of seizure.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
Dalfampridine is usually taken once every 12 hours. Follow your doctor's dosing instructions very carefully.
Do not crush, chew, or break an extended-release tablet. Swallow it whole. Do not dissolve the tablet in liquid. Breaking or dissolving the pill may cause too much of the drug to be released at one time which can increase your risk of a seizure.
Dalfampridine may be taken with or without food.
Do not take more than 2 tablets in a 24-hour period.
To be sure this medicine is not causing harmful effects, your kidney function may need to be checked often.
Store at room temperature away from moisture and heat.
Throw away any leftover medicine after the expiration date on the label has passed.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose can cause confusion, problems with thinking or memory, tremors, sweating, or seizures.
What should I avoid while taking dalfampridine?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Dalfampridine side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop taking dalfampridine and call your doctor at once if you have:
a seizure (convulsions);
pain or burning when you urinate;
numbness, burning pain, or tingly feeling;
problems with balance; or
relapse or worsening of MS symptoms.
Common side effects may include:
sleep problems (insomnia);
stuffy nose, sinus pain, sore throat; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect dalfampridine?
Other drugs may interact with dalfampridine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 5.01.
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- Drug class: miscellaneous central nervous system agents