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Medically reviewed: September 25, 2017
Medically reviewed on February 28, 2018.
What is sumatriptan injection?
Sumatriptan is a headache medicine that narrows blood vessels around the brain. Sumatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms.
Sumatriptan is used to treat migraine headaches and cluster headaches in adults. Sumatriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.
Sumatriptan should not be used to treat a common tension headache or a headache that causes loss of movement on one side of your body. Use this medicine only if your condition has been confirmed by a doctor as migraine headaches.
Sumatriptan may also be used for purposes not listed in this medication guide.
You should not use sumatriptan if you have ever had heart disease, coronary artery disease, blood circulation problems, Wolff-Parkinson-White syndrome, uncontrolled high blood pressure, severe liver disease, a heart attack or stroke, or if your headache seems to be different from your usual migraine headaches.
Do not use sumatriptan within 24 hours before or after using another migraine headache medicine.
Before taking this medicine
You should not use sumatriptan if you are allergic to it, or if you have ever had:
heart disease, heart attack, or stroke (including "mini-stroke");
coronary artery disease, angina (chest pain), blood circulation problems, lack of blood supply to the heart;
circulation problems affecting your legs, arms, stomach, intestines, or kidneys;
a heart disorder called Wolff-Parkinson-White syndrome;
uncontrolled high blood pressure;
severe liver disease; or
a headache that seems different from your usual migraine headaches.
Do not use sumatriptan if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
To make sure sumatriptan is safe for you, tell your doctor if you have ever had:
liver or kidney disease;
epilepsy or other seizure disorder;
high blood pressure, a heart rhythm disorder; or
risk factors for coronary artery disease (such as diabetes, menopause, smoking, being overweight, having high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).
Sumatriptan can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medicine.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant. Your name may need to be listed on a sumatriptan pregnancy registry.
Sumatriptan can pass into breast milk, but effects on the nursing baby are not known. To avoid exposing your baby to sumatriptan in breast milk, do not breast-feed for 12 hours after using an injection. If you use a breast pump during this time, throw out any milk you collect.
Sumatriptan injection is not approved for use by anyone younger than 18 years old.
How should I use sumatriptan injection?
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended. Overuse of migraine headache medicine can actually make your headaches worse.
Sumatriptan is injected under the skin. You may be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of used needles and syringes.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
Use sumatriptan as soon as you notice headache symptoms, or after an attack has already begun.
Sumatriptan injection comes in a vial (bottle), an auto-injector or prefilled cartridge to be loaded into an auto-injector syringe, or in a needle-free injector device. Each vial, cartridge, or needle-free device is for one use only.
After using an injection: If your headache does not completely go away after the injection, call your doctor before using a second sumatriptan injection. If your headache goes away and then comes back, you may use a second injection if it has been at least one (1) hour since your first injection. Do not use more than two (2) injections in 24 hours. If your symptoms do not improve, contact your doctor before using any more injections.
Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.
Store at room temperature away from moisture, heat, and light. Throw away any unused medicine after the expiration date on the label has passed.
What happens if I miss a dose?
Since sumatriptan is used as needed, it does not have a daily dosing schedule. Call your doctor promptly if your symptoms do not improve after using sumatriptan.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include tremors, skin redness, scabs or scaly skin where you injected the medicine, weakness, lack of coordination, breathing problems, blue-colored lips or fingernails, vision problems, seizure (convulsions), or loss of movement in any part of your body.
What should I avoid while using sumatriptan injection?
Do not use sumatriptan within 24 hours before or after using another migraine headache medicine, including:
Sumatriptan may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Sumatriptan injection side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using sumatriptan and call your doctor if you have:
sudden and severe stomach pain and bloody diarrhea;
severe chest pain, shortness of breath, irregular heartbeats;
a seizure (convulsions);
dangerously high blood pressure--severe headache, blurred vision, pounding in your neck or ears, nosebleed, anxiety;
heart attack symptoms--chest pain or pressure, tightness or pain spreading to your jaw or shoulder, nausea, sweating;
signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance; or
Common side effects may include:
numbness or burning sensation;
pressure or heavy feeling in any part of your body;
dizziness, drowsiness, feeling weak or tired;
neck pain or stiffness;
flushing (warmth, redness, or tingly feeling); or
pain, redness, bleeding, swelling, or bruising where you injected the medicine.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect sumatriptan injection?
Using sumatriptan while you are using certain other medicines can cause high levels of serotonin to build up in your body, a condition called "serotonin syndrome," which can be fatal. Tell your doctor if you also use:
medicine to treat depression;
medicine to treat a psychiatric disorder;
a narcotic (opioid) medication; or
medicine to prevent nausea and vomiting.
This list is not complete. Other drugs may interact with sumatriptan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 8.01.
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- Drug class: antimigraine agents