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Akynzeo

Generic Name: netupitant and palonosetron (net UE pi tant and PAL oh NOE se tron)
Brand Name: Akynzeo

Medically reviewed on December 8, 2017

What is netupitant and palonosetron?

Netupitant and palonosetron is a combination medicine used in adults to prevent nausea and vomiting caused by medicine to treat cancer (chemotherapy).

Netupitant and palonosetron helps prevent nausea and vomiting that occurs both during your chemotherapy treatment, or that occurs later on (delayed nausea and vomiting).

Netupitant and palonosetron is not for preventing nausea or vomiting caused by factors other than chemotherapy.

Netupitant and palonosetron may also be used for purposes not listed in this medication guide.

Important Information

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use this medicine if you are allergic to netupitant or palonosetron.

To make sure netupitant and palonosetron is safe for you, tell your doctor if you have:

FDA pregnancy category C. It is not known whether netupitant and palonosetron will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether netupitant and palonosetron passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Netupitant and palonosetron is not approved for use by anyone younger than 18 years old.

How should I take netupitant and palonosetron?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Netupitant and palonosetron is usually taken 1 hour before the start of chemotherapy. Follow your doctor's instructions.

You may take netupitant and palonosetron with or without food.

This medicine is given ahead of time and will not treat nausea or vomiting you already have.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking netupitant and palonosetron?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Netupitant and palonosetron side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; chest pain, difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect netupitant and palonosetron?

Other drugs may interact with netupitant and palonosetron, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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