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Generic Name: pegademase bovine (peg AD e mase BOE vine)
Brand Name: Adagen

Medically reviewed by on Dec 5, 2019 – Written by Cerner Multum

What is Adagen?

Adagen is a man-made form of an enzyme called adenosine deaminase (ADA). ADA is important in the body for preventing the buildup of certain proteins harmful to the white blood cells that help your body fight infections.

Adagen is used to replace ADA in people with severe combined immunodeficiency disease (SCID).

Adagen may also be used for purposes not listed in this medication guide.

Important Information

You should not use Adagen if have severe thrombocytopenia (low levels of platelets in blood).

Before taking this medicine

You should not use Adagen if you are allergic to it, or if you have:

  • severe thrombocytopenia (low levels of platelets in blood).

To make sure Adagen is safe for you, tell your doctor if you have:

  • easy bruising or bleeding.

FDA pregnancy category C. It is not known whether Adagen will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Adagen.

It is not known whether pegademase bovine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I use Adagen?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Adagen is injected into a muscle. You may be shown how to use injections at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles and syringes.

Adagen is usually given once every 7 days. Follow your doctor's dosing instructions very carefully.

Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

Each single-use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.

Do not use Adagen if it has changed colors or has particles in it. Call your pharmacist for new medication.

While using Adagen, your blood will need to be tested often.

It may take up to 6 months before your immune system improves and you have fewer infections. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

Call your doctor if your symptoms do not improve after the first few weeks of treatment.

Store in the refrigerator, do not freeze. Throw away the medicine if it has become frozen.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of Adagen.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Adagen?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Adagen side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

  • pale or yellowed skin, dark colored urine, fever, confusion or weakness; or

  • signs of infection--fever, chills, sore throat, mouth sores, flu symptoms, skin sores or swelling.

Common side effects may include:

  • headache; or

  • redness or itching where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Adagen?

Other drugs may interact with pegademase bovine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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