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What treats Bubonic Plague?

Medically reviewed by Melisa Puckey, BPharm. Last updated on June 26, 2024.

Which antibiotics treats bubonic Plague? What drug treats bubonic plague?

Official answer


What medication treats bubonic plague?

Bubonic plague is a bacterial infection caused by the bacteria Yersinia pestis which can be effectively treated with antibiotics. If bubonic plague is left untreated, the infection can spread and progress to septicemic plague and may even infect the lungs to become secondary pneumonic plague. Treatment with antibiotics is essential to prevent severe complications and even death.

Antibiotics used to treat bubonic plague:

Antibiotic IV, IM or Oral* Dose
Ciprofloxacin IV
IV dose 400 mg every 8-12 hour
Oral dose 500mg-750 mg twice daily
Chloramphenicol IV 25 mg/kg every 6 hours
Doxycycline IV or Oral 100 mg twice daily or 200 mg once daily
Levofloxacin IV or Oral 500 mg once daily
Moxifloxacin IV or Oral 400 mg once daily

*IV = intravenous injection, IM =Intramuscular injection, Oral = oral medication that is swallowed

It is important to start IV antibiotic treatment as soon as possible in suspected bubonic plague. If possible pretreatment samples should be taken, but treatment should not be delayed by waiting for results.

Antibiotics can be changed from IV antibiotics to oral antibiotics once the patients' condition has improved.

Antibiotic treatment is usually 10 to 14 days, or until 2 days after the fever has finished.

For more information on plague symptoms, complications and risk factors click here: Plague

Bottom line:

  • Bubonic plague is a bacterial infection caused by the bacteria Yersinia pestis.
  • Bubonic plague can successfully be treated with specific antibiotics.
  • If bubonic plague is not treated, the infection can lead to serious complications including death.

CDC Plague Information for Healthcare Professionals Medication to treat Plague: t

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