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How do you use Eucrisa (crisaborole) ointment?

Medically reviewed by Melisa Puckey, BPharm. Last updated on Feb 23, 2023.

Answers to the most common questions asked about Eucrisa ointment.

Official answer


Apply a thin layer to the area of skin that has eczema. Apply it two times each day. You should wash your hands after applying it unless you are treating eczema on your hands.

What is Eucrisa used for?

  • Eucrisa (crisaborole) 2% ointment is used to treat mild to moderate eczema (atopic dermatitis) in patients that are 3 months or older.

How does it work?

  • The active ingredient crisaborole blocks an enzyme in immune cells called phosphodiesterase 4 (PDE4), which helps balance the immune response and improves eczema.

Is it a steroid ointment?

  • Eucrisa is not a steroid ointment, so does not have the side effects of a steroid ointment.

Where can it be used? (Can it be used on your face?)

  • It can be used on any skin, including the face.
  • It should not be used in your eyes, mouth or vagina.

How long does it take to work?

  • In clinical trial (AD-302: NCT02118792) about 10% of patients saw an improvement in their eczema after one week, and at the end of the 28 day trial 31.4% of patients using Eucrisa had clear/almost clear results compared to 18% of patients using plain ointment base.

How long can you use Eucrisa?

  • You should use it for as long as your doctor has told you to use it.
  • The clinical trial (AD-303) studied the safety of using Eucrisa for 48 weeks in patients over 2 years of age. The result was that it had a favorable safety profile. There was a low amount of side effects which were mostly mild to moderate and there was no increase in side effects over time.

What are the side effects?

  • The most common side effect is burning or stinging in the area where Eucrisa has been applied.


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