Skip to main content

Occipital nerve stimulation: Effective migraine treatment?

Medically reviewed by Last updated on Jul 25, 2022.

Occipital nerve stimulation is a surgical procedure that may be useful in the treatment of chronic and severe headache disorders, such as chronic migraines, that do not respond well to other therapies.

Occipital nerve stimulation was first used to treat headaches in 1977, but it's still considered a treatment in development.

The occipital nerve originates at the base of the neck. In occipital nerve stimulation, your doctor implants a small device at the base of the skull with leads connected to a power source (pulse generator) that sends electrical impulses to the occipital nerve.

The pulse generator is often implanted under the collarbone (clavicle), but the abdominal and buttock (gluteal) areas also are options.

Risks associated with occipital nerve stimulation include the possible need for surgical revision of wire placement after the procedure, as well as infection, pain and muscle spasms.

Research shows occipital nerve stimulation may improve headaches for some people, but the results are inconsistent.

In addition, studies on occipital nerve stimulation so far have included only a small number of participants, and long-term results are limited.

One study suggested about 40 percent of people with chronic migraine reported a sustained benefit up to four years after occipital nerve stimulation. Another suggested a similar benefit for people with chronic cluster headache up to six years after treatment. But both of these studies were without a blinded comparison group (uncontrolled), and a placebo effect may explain some of these benefits.

The bottom line? Although there's some evidence that occipital nerve stimulation may be effective in the treatment of chronic headache disorders, more studies are needed before the approach can be considered a routine headache treatment.

© 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. Terms of use.