Label Changes for:
Wellbutrin XL (bupropion hydrochloride) Extended-Release Tablets Aplenzin (bupropion hydrobromide) Extended-Release Tablets
Changes have been made to the PRECAUTIONS sections of the safety label.
Detailed View: Safety Labeling Changes Approved By FDA Center for Drug Evaluation and Research (CDER) – July 2011
- information regarding drug-drug interactions between bupropion and drugs that inhibit or induce CYP2B6, such as ritonavir or efavirenz
- information about potential interactions between bupropion and drugs which require metabolic activation by CYP2D6 in order to be effective (e.g., tamoxifen)
Drug-Laboratory Test Interactions
- False-positive urine immunoassay screening tests for amphetamines have been reported in patients taking bupropion. This is due to.....
- added.......content re: false positive test results for amphetamines