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Label Changes for:

Reyataz (atazanavir sulfate) Capsules

August 2008

Changes have been made to the CONTRAINDICATIONS, PRECAUTIONS and PATIENT PACKAGE INSERT sections of the safety label.

Detailed View: Safety Labeling Changes Approved By FDA Center for Drug Evaluation and Research (CDER) -- August 2008


The detailed view includes drug products with safety labeling changes to the BOXED WARNING, CONTRAINDICATIONS, WARNINGS, PRECAUTIONS, ADVERSE REACTIONS, or PATIENT PACKAGE INSERT/MEDICATION GUIDE sections. Deletions or editorial revisions made to these sections are not included in this summary.

Summary View


Sections Modified Summary of Changes to Contraindications and Warnings


  • Table 3: Drugs That Are Contraindicated with Reyataz
    • Benzodiazepines


  • Potential for Reyataz to Affect Other Drugs
  • Established and Other Potentially Significant Drug Interactions
    • Table 10
      • HIV Antiviral Agents
      • Other Agents
  • Drugs with No Observed or Predicted Interactions with Reyataz


  • What important information should I know about taking Reytataz with other medicines?
    • Midazolam, also known as Versed (used for sedation), when taken by mouth.
  • Do not take the following medicines with Reyataz because they may lower the amount of Reyataz in your blood...
    • Viramune (nevirapine, used for HIV infection).
  • Talk to your healthcare provider about choosing an effective method of contraception...


See Table 3: Drugs That Are Contraindicated with Reyataz:

Triazolam and orally administered midazolam are extensively metabolized by CYP3A4. Coadministration of triazolam or orally administered midazolam with Reyataz may cause large increases in the concentration of these benzodiazepines...