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In the US, Trametinib (trametinib systemic) is a member of the drug class multikinase inhibitors and is used to treat Melanoma - Metastatic, Non-Small Cell Lung Cancer and Thyroid Cancer.

US matches:



ATC (Anatomical Therapeutic Chemical Classification)


CAS registry number (Chemical Abstracts Service)


Chemical Formula


Molecular Weight


Therapeutic Category

Antineoplastic agent

Chemical Name

N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimetyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide (WHO)

Foreign Names

  • Trametinibum (Latin)
  • Trametinib (German)
  • Tram├ętinib (French)
  • Trametinib (Spanish)

Generic Names

  • Trametinib (OS: USAN)
  • GSK 1120212 (IS)
  • JTP-74057 (IS)
  • UNII-33E86K87QN (IS)
  • Trametinib Dimethyl Sulfoxide (OS: USAN)
  • GSK 1120212B (IS)

Brand Names

  • Mekinist
    Glaxo Group, Poland; GlaxoSmithKline, Canada; GlaxoSmithKline, Croatia (Hrvatska); Novartis Europharm, Slovenia; GlaxoSmithKline, Australia; GlaxoSmithKline, United States; Novartis Pharma, Germany; Novartis Pharmaceuticals UK, United Kingdom


ISInofficial Synonym
OSOfficial Synonym
Rec.INNRecommended International Nonproprietary Name (World Health Organization)
USANUnited States Adopted Name
WHOWorld Health Organization

Further information on drug naming conventions: International Nonproprietary Names.

Important Notice: The international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

Further information

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