Skip to Content




ATC (Anatomical Therapeutic Chemical Classification)


CAS registry number (Chemical Abstracts Service)


Therapeutic Categories

Hemostatic agent

Blood coagulation factor substitute

Chemical Name

A protein (serine protease) of either human or bovine origin which consists of two polypeptide chains, designated A and B, covalently linked by a disulfide bridge. It is a key enzyme in the coagulation cascade

Foreign Names

Generic Names

  • Thrombin (OS: JAN)
  • Thrombine (OS: DCF)
  • Trombina (OS: DCIT)
  • Blood Coagulation Factor lla (IS)
  • Coagulation factor IIa, human (IS)
  • Fibrinogenase (IS)
  • UNII-6K15ABL77G (IS)
  • Thrombin (PH: JP XVII)

Brand Names

  • Artiss [+ Aprotinin, + Fibrinogen, Human, + Calcium Chloride]
    Baxter, Austria; Baxter, Canada; Baxter, Switzerland; Baxter, Czech Republic; Baxter, Germany; Baxter, Denmark; Baxter, Spain; Baxter, Finland; Baxter, Ireland; Baxter, Norway; Baxter, Sweden; Baxter Healthcare, Australia; Baxter Healthcare, United Kingdom; Baxter Nederland, Netherlands; Baxter SA, Belgium; Baxter SA, Luxembourg
  • Artiss [+ Calcium chloride, + Fibrinogen, + Factor XIII, + Aprotinin]
    Baxter, New Zealand
  • Artiss [+ Fibrinogen]
    Baxter, United States
  • Beriplast P [+ Aprotinin, + Calcium Chloride, + Coagulation Factor XIII, Human, + Fibrinogen, Human]
    Biotoscana, Colombia; CSL Behring, Argentina; CSL Behring, Germany; CSL Behring, Hong Kong; CSL Behring, Italy; CSL Behring, Slovenia; CSL Behring, Turkey; CSL Behring GmbH, Mexico; Nycomed, Spain; PharmaSwiss, Serbia
  • BioTrombina 400
    Biomed Lublin, Poland
  • Evarrest [+ Fibrinogen]
    Ethicon, United States; OMRIX, Germany; OMRIX, Estonia; OMRIX, France; OMRIX, Poland; Omrix Biopharmaceuticals, Lithuania; Omrix Biopharmaceuticals, Sweden
  • Evicel [+ Fibrinogen, Human, + Plasma Fibronectin]
    OMRIX, Belgium; OMRIX, Denmark; OMRIX, Norway
  • EVICEL [+ Fibrinogen, Human, + Plasma Fibronectin]
    Janssen-Cilag, Switzerland; OMRIX, Germany
  • EVICEL [+ Fibrinogen, Human]
    Ethicon, United States; OMRIX, Slovenia; Omrix Biopharmaceuticals, Sweden
  • Evicel [+ Fibrinogen, Human]
    Johnson & Johnson Medical, Australia; Omrix, Austria; Omrix, Estonia; Omrix, France; Omrix, Poland; Omrix Biopharmaceuticals, Canada; Omrix Biopharmaceuticals, Finland
  • Evithrom
    Ethicon, United States
  • Fibingluraas [+ Fibrinogen]
    RAAS Blood Products, China; Shanghai RAAS Blood Products, Thailand
  • Gastrotrombina
    Biomed Lublin, Poland
  • Kang Li Ning
    Hualan Biological Engineering, China
  • Quixil [+ Fibrinogen, + Fibronectin, + Calcium Chloride]
    Omrix Biopharmaceutical-B, Italy
  • Raplixa [+ Fibrinogen, Human]
    Mallinckrodt, Estonia; Mallinckrodt, Lithuania; Mallinckrodt, Latvia; Mallinckrodt, Sweden; Mallinckrodt Pharmaceuticals, Netherlands
  • Sai Bai
    Sun Pharmaceutical Industries, China
  • ShuPing LaiShi
    RAAS Blood Products, China
  • Siduopu
    Binhai Xinbao, China
  • TachoComb [+ Fibrinogen, Human, + Aprotinin, + Riboflavin]
    Nycomed, Lithuania
  • Tachocomb [+ Fibrinogen]
    Takeda, Georgia
  • TachoSil [+ Fibrinogen, Human]
    CSL Behring, Japan; Nycomed, France; Nycomed, Portugal; Nycomed Italia, Italy; Takeda, Australia; Takeda, Brazil; Takeda, Czech Republic; Takeda, Germany; Takeda, Spain; Takeda, Finland; Takeda, Hong Kong; Takeda, Croatia (Hrvatska); Takeda, Hungary; Takeda, Ireland; Takeda, Israel; Takeda, Lithuania; Takeda, Luxembourg; Takeda, Latvia; Takeda, Macedonia; Takeda, Malaysia; Takeda, Norway; Takeda, Poland; Takeda, Slovakia; Takeda Austria, Slovenia; Takeda Austria GmbH, Greece; Takeda Austria GmbH, Iceland; Takeda Belgium, Belgium; Takeda Canada, Canada; Takeda GmbH, Estonia; Takeda Nederland, Netherlands; Takeda Pharma, Austria; Takeda Pharma, Switzerland; Takeda Pharma, Denmark; Takeda Pharma, Sweden; Takeda Pharmaceuticals U.S.A, United States; Takeda UK, United Kingdom
  • Thrombin
    Chemo-Sero-Therapeutic Research Institut Kaketsuken, Japan; Fuji Seiyaku, Japan; Japan Blood Products Organization, Japan; Mochida Pharmaceutical, Japan; Nihon Seiyaku, Japan; Sawai Seiyaku, Japan
  • Thrombin-JMI
    King Pharmaceuticals, United States
  • Tisseel [+ Aprotinin, + Calcium Chloride, + Coagulation Factor XIII, Human, + Fibrinogen, Human]
    Baxter, Austria; Baxter, Canada; Baxter, Switzerland; Baxter, Denmark; Baxter, Finland; Baxter, Hong Kong; Baxter, Hungary; Baxter, Ireland; Baxter, Luxembourg; Baxter, Norway; Baxter, New Zealand; Baxter, Sweden; Baxter Medical AB, Iceland; Baxter Nederland, Netherlands; Baxter SA, Belgium; Dalim, South Korea
  • Tisseel [+ Aprotinin, + Calcium Chloride, + Fibrinogen, Human]
    Baxter, Bulgaria; Baxter, Czech Republic; Baxter, Germany; Baxter, Spain; Baxter, Greece; Baxter Healthcare, United Kingdom; Baxter Healthcare, Malta
  • Tisseel [+ Fibrinogen]
    Baxter, United States
  • TISSEEL Lyo [+ Aprotinin, + Calcium Chloride, + Coagulation Factor XIII, Human, + Fibrinogen, Human]
    Baxter, Ireland
  • Tisseel VH S/D [+ Aprotinin, + Fibrinogen, Human, + Coagulation Factor XIII, Human, + Calcium Chloride]
    Baxter Healthcare, Australia
  • Tisseel-Lyo [+ Fibrinogen]
    Eczacibasi Baxter, Turkey
  • Tissucol [+ Aprotinin, + Calcium Chloride, + Coagulation Factor XIII, Human, + Fibrinogen, Human]
    Baxter, Brazil
  • Trombinas
    Vilniaus kraujo centras, Lithuania
  • VeraSeal [+ Fibrinogen]
    Grifols, Netherlands


DCFDénomination Commune Française
DCITDenominazione Comune Italiana
ISInofficial Synonym
JANJapanese Accepted Name
OSOfficial Synonym
PHPharmacopoeia Name
Rec.INNRecommended International Nonproprietary Name (World Health Organization)

Further information on drug naming conventions: International Nonproprietary Names.

Important Notice: The international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.