Skip to Content




ATC (Anatomical Therapeutic Chemical Classification)


CAS registry number (Chemical Abstracts Service)


Therapeutic Categories

Hemostatic agent

Blood coagulation factor substitute

Chemical Name

A protein (serine protease) of either human or bovine origin which consists of two polypeptide chains, designated A and B, covalently linked by a disulfide bridge. It is a key enzyme in the coagulation cascade

Foreign Names

Generic Names

  • Thrombin (OS: JAN)
  • Thrombine (OS: DCF)
  • Trombina (OS: DCIT)
  • Blood Coagulation Factor lla (IS)
  • Coagulation factor IIa, human (IS)
  • Fibrinogenase (IS)
  • UNII-6K15ABL77G (IS)
  • Thrombin (PH: JP XVI)

Brand Names

  • Artiss (Thrombin and Aprotinin, + Fibrinogen, Human, + Calcium Chloride)
    Baxter, Belgium; Baxter, Bulgaria; Baxter, Switzerland; Baxter, Germany; Baxter, Finland; Baxter, Norway; Baxter, Sweden
  • Artiss (Thrombin and Fibrinogen)
    Baxter, United States
  • Beriplast (Thrombin and Calcium Chloride)
    Takeda France, France
  • Beriplast P (Thrombin and Aprotinin, + Calcium Chloride, + Coagulation Factor XIII, Human, + Fibrinogen, Human)
    Biotoscana, Colombia; CSL Behring, Austria; CSL Behring, Switzerland; CSL Behring, Germany; CSL Behring, Hong Kong; CSL Behring, Netherlands; CSL Behring, Serbia; Farma-Tek, Turkey; Nycomed, Spain; Takeda, Germany
  • BioTrombina
    Biomed Lublin, Poland
  • Evarrest (Thrombin and Fibrinogen)
    Ethicon, United States; Omrix, Poland
  • Evicel (Thrombin and Fibrinogen, Human, + Plasma Fibronectin)
    OMRIX, Belgium; OMRIX, Denmark; OMRIX, Norway
  • EVICEL (Thrombin and Fibrinogen, Human, + Plasma Fibronectin)
    Janssen-Cilag, Switzerland; OMRIX, Germany
  • EVICEL (Thrombin and Fibrinogen, Human)
    OMRIX, Slovenia; Omrix Biopharmaceutical-B, Italy; Omrix Biopharmaceuticals, Sweden
  • Evicel (Thrombin and Fibrinogen, Human)
    Omrix, Austria; Omrix, Poland
  • Fibingluraas (Thrombin and Fibrinogen)
    Shanghai Raas, China; Shanghai RAAS Blood Products, Thailand
  • Gastrotrombina
    Biomed Lublin, Poland
  • Tachocomb (Thrombin and Fibrinogen)
    Nycomed, Georgia
  • TachoSil (Thrombin and Fibrinogen, Human)
    Baxter, United States; CSL Behring, Japan; Nycomed, Czech Republic; Nycomed, Spain; Nycomed, Greece; Nycomed, Hungary; Nycomed, Iceland; Nycomed, Latvia; Nycomed, Portugal; Nycomed, Romania; Orifarm, Norway; Takeda, Bosnia & Herzegowina; Takeda, Belgium; Takeda, Germany; Takeda, Finland; Takeda, Hong Kong; Takeda, Croatia (Hrvatska); Takeda, Ireland; Takeda, Israel; Takeda, Italy; Takeda, Malaysia; Takeda, Norway; Takeda, Poland; Takeda, Slovakia; Takeda Austria, Slovenia; Takeda Pharma, Austria; Takeda Pharma, Switzerland; Takeda Pharma, Sweden; Takeda UK, United Kingdom
  • Thrombin
    Mochida Pharmaceutical, Japan
  • Thrombin Benesis
    Japan Blood Products Organization, Japan
  • Thrombin F
    Fuji Seiyaku, Japan
  • Thrombin I
    Nihon Seiyaku, Japan
  • Thrombin Sawai
    Sawai Seiyaku, Japan
  • Tisseel (Thrombin and Aprotinin, + Calcium Chloride, + Coagulation Factor XIII, Human, + Fibrinogen, Human)
    Baxter, Austria; Baxter, Switzerland; Baxter, Finland; Baxter, Hong Kong; Baxter, Iceland; Baxter, Netherlands; Baxter, Norway; Baxter, Sweden; Baxter-A, Italy; Dalim, South Korea
  • Tisseel (Thrombin and Fibrinogen)
    Baxter, United States
  • Tisseel-Lyo (Thrombin and Fibrinogen)
    Eczacibasi Baxter, Turkey
  • Tissucol (Thrombin and Aprotinin, + Calcium Chloride, + Coagulation Factor XIII, Human, + Fibrinogen, Human)
    Baxter, Germany
  • Tissucol Duo (Thrombin and Aprotinin, + Calcium Chloride, + Coagulation Factor XIII, Human, + Fibrinogen, Human)
    Baxter, Germany
  • Trombinas
    Vilniaus kraujo centras, Lithuania


DCFDénomination Commune Française
DCITDenominazione Comune Italiana
ISInofficial Synonym
JANJapanese Accepted Name
OSOfficial Synonym
PHPharmacopoeia Name
Rec.INNRecommended International Nonproprietary Name (World Health Organization)

Further information on drug naming conventions: International Nonproprietary Names.

Important Notice: The international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.