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Tetrabenazine

In the US, Tetrabenazine (tetrabenazine systemic) is a member of the drug class VMAT2 inhibitors and is used to treat Huntington's Disease and Tardive Dyskinesia.

US matches:

UK matches:

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

N05AK01

CAS registry number (Chemical Abstracts Service)

0000058-46-8

Chemical Formula

C19-H27-N-O3

Molecular Weight

317

Therapeutic Categories

Treatment of Huntington's disease

Vesicular monoamine transporter 2 (VMAT2) inhibitor

Chemical Names

(RS)-2,3,4,6,7,11b-Hexahydro-3-isobutyl-9-10-dimetoxy-1H-benzo[a]chinolizin-2-on (IUPAC)

1,2,3,4,6,7-hexahydro-3-isobutyl-9,10-dimetoxy-2-oxo-11bH-benzo[a]quinolizine (WHO)

1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimetoxy-2H-benzo[a]quinolizin-2-one (WHO)

2H-Benzo(a)quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimetoxy-

2H-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimetoxy-3-(2-metylpropyl)-

2-oxo-3-isobutyl-9,10-dimetoxy-1,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizine

9,10-Dimetoxy-3-(2-metylpropyl)-1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizin-2-one (BAN)

Foreign Names

  • Tetrabenazinum (Latin)
  • Tetrabenazin (German)
  • TĂ©trabĂ©nazine (French)
  • Tetrabenazina (Spanish)

Generic Names

  • Tetrabenazine (OS: BAN, JAN)
  • 5-21-13-00178 (Beilstein) (IS)
  • AI3-52046 (IS)
  • BRN 0040090 (IS)
  • EINECS 200-383-6 (IS)
  • NSC 169886 (IS)
  • Ro 1-9569 (IS)

Brand Names

  • Apo-Tetrabenazine
    Apotex, Canada
  • Artesyd
    AOP Orphan, Romania
  • Choreazine
    Alfresa Pharma, Japan
  • Dystardis
    AOP Orphan, Bulgaria; AOP Orphan, Poland; AOP Orphan Pharmaceuticals, Finland
  • Dystardis 25 mg
    AOP Orphan, Austria
  • Feinardon
    Tuteur, Argentina
  • Motetis
    Douglas, New Zealand
  • Motetis 25 mg
    AOP, Hungary
  • Nitoman
    Cambridge, Taiwan; Hormosan Pharma, Germany; MediLink, Denmark; UCB, Spain; Valeant Canada, Canada
  • PMS-Tetrabenazine
    Pharmascience, Canada
  • Revocon
    Tri Healthcare, Malta
  • Tardiben
    AOP Orphan, Norway
  • Tetmodis
    AOP Orphan, Bosnia & Herzegowina; AOP Orphan Pharma, Estonia; AOP Orphan Pharmaceuticals, Denmark; AOP Orphan Pharmaceuticals, Finland; AOP Orphan Pharmaceuticals, Latvia; AOP Orphan Pharmaceuticals, Macedonia; AOP Orphan Pharmaceuticals, Sweden; AOP Orphan Pharmaceuticals AG, Czech Republic; Axon Pharma, Chile; Axon Pharma, Peru; Bluefish, France; Orpha Devel, Netherlands; Orpha-Devel, Lithuania; Orpha-Devel, Poland; Orpha-Devel, Romania; Orphan Europe, Spain; Providens, Croatia (Hrvatska); Trommsdorff, Bulgaria; Vanquish, Mexico
  • Tetmodis 25mg
    AOP Orphan, Austria; Desitin, Germany
  • Tetrabenazine
    Actavis Labs, United States; Apicore US, United States; Bionpharma, United States; Central Procurement & Supplies Unit, Malta; Cherubino, Malta; Hetero, United States; Ranbaxy, United Kingdom; Sun Pharma, United States
  • Tetrabenazine AOP Orphan Pharmaceuticals
    AOP Orphan Pharmaceuticals, Belgium
  • Tetrabenazine iNova
    iNova Pharmaceuticals, Australia
  • Tetrabenazine SteriMax
    SteriMax, Canada
  • Tetrabenazine SUN
    Sun Pharma, Netherlands
  • Tetrabenz
    Lafedar, Argentina
  • Tetrazol
    Bago, Argentina
  • Trenazin
    Teva Argentina, Argentina
  • Xenazina
    Chiesi Farmaceutici, Italy
  • Xenazine
    Central Procurement & Supplies Unit, Malta; EUSA Pharma, France; IFET, Greece; MediLink, Sweden; Pharmachemic Trading Agency, Malta; PharmaSwiss, Greece; PharmaSwiss, Lithuania; PharmaSwiss, Netherlands; PharmaSwiss, Poland; PharmaSwiss, Slovenia; Valeant Pharmaceuticals International, United States
  • Xenazine 25
    AFT, New Zealand
  • Xenazine 25mg
    Curatis, Switzerland; Recipharm, Israel

Glossary

TermDefinition
BANBritish Approved Name
IUPACInternational Union of Pure and Applied Chemistry
ISInofficial Synonym
JANJapanese Accepted Name
OSOfficial Synonym
Rec.INNRecommended International Nonproprietary Name (World Health Organization)
WHOWorld Health Organization

Further information on drug naming conventions: International Nonproprietary Names.

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