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In the US, Siltuximab (siltuximab systemic) is a member of the drug class interleukin inhibitors and is used to treat Multicentric Castleman’s Disease.

US matches:



ATC (Anatomical Therapeutic Chemical Classification)


CAS registry number (Chemical Abstracts Service)


Chemical Formula


Molecular Weight


Therapeutic Category

Antineoplastic agent

Chemical Name

immunoglobulin G1-kappa, anti-[Homo sapiensinterleukin 6 (IL6,IL-6)], chimeric monoclonal antibody;gamma1 heavy chain (1-449)[Mus musculusVH (IGHV5-9-4*01-(IGHD)-IGHJ4*01)[8.8.12](1-119)-Homo sapiensIGHG1*01 (120-449)], (222-213')-disulfide with kappa lig (WHO)

Foreign Names

  • Siltuximabum (Latin)
  • Siltuximab (German)
  • Siltuximab (French)
  • Siltuximab (Spanish)

Generic Names

  • Siltuximab (OS: USAN)

Brand Names

  • Sylvant
    Janssen, Finland; Janssen, Ireland; Janssen, Sweden; Janssen Biotech, United States; Janssen-Cilag, Switzerland; Janssen-Cilag, Germany; Janssen-Cilag, Denmark; Janssen-Cilag, United Kingdom; Janssen-Cilag, Greece; Janssen-Cilag, Poland; Janssen-Cilag International, Austria; Janssen-Cilag International NV, Slovenia; Johnson & Johnson, Croatia (Hrvatska)


ISInofficial Synonym
OSOfficial Synonym
Rec.INNRecommended International Nonproprietary Name (World Health Organization)
USANUnited States Adopted Name
WHOWorld Health Organization

Further information on drug naming conventions: International Nonproprietary Names.

Important Notice: The international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

Further information

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