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Posaconazole

In some countries, this medicine may only be approved for veterinary use.

In the US, Posaconazole (posaconazole systemic) is a member of the drug class azole antifungals and is used to treat Aspergillosis - Invasive, Candidemia and Oral Thrush.

US matches:

UK matches:

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

J02AC04

CAS registry number (Chemical Abstracts Service)

0171228-49-2

Chemical Formula

C37-H42-F2-N8-O4

Molecular Weight

700

Therapeutic Category

Antifungal agent

Chemical Names

(3R-cis)-4-[4-[4-[4-[5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmetyl)tetrahydrofuran-3-ylmetoxy]-phenyl]piperazin-1-yl]phenyl]-2-[1(S)-etyl-2(S)-hydroxypropyl]-3,4-dihydro-2H-1,2,4 -triazol-3-one

1-[(1S,2S)Etyl-2-hydroxypropyl]-2,3-dihydro-4-{4-[4-(4-{2-[(2S,4R)-(1,2,4-triazol-1-ylmetyl)-2-(2,4-difluorphenyl)oxolan-4-ylmetyl]phenyl}piperazin-1-yl)phenyl]}-1,2,4-triazol-3-on (IUPAC)

2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-(4-[1-(1S,2S)-1-etyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]metyl]-1-(1H-1,2,4-triazol-1-yl)-D-treo-pentitol

3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-yl-metyl)-3-furanyl]metoxy]phenyl]-1-piperazinyl]phenyl]-2-(1-etyl-2-hydroxypropyl)-2,4-dihydro-, [3R-[3α(1S*,2S*),5α]]- (USAN)

4-[4-(4-{4-[(3R,5R)-5-]2,4-Difluorophenyl}tetrahydro-5-(1H-1,2,4-triazol-1-ylmetyl)-3-furylmetoxy]phenyl}piperazin-1-yl)phenyl]-2-[(1S,2S)-1-etyl-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one (BAN)

4-[p-[4-[p-[[(3R,5R)-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmetyl)-3-furyl]metoxy]phenyl]-1-piperazinyl]phenyl]-1-[(1S,2S)-1-etyl-2-hydroxypropyl]-delta²-1,2,4-triazolin-5-one (WHO)

Foreign Names

  • Posaconazolum (Latin)
  • Posaconazol (German)
  • Posaconazole (French)
  • Posaconazol (Spanish)

Generic Names

  • Posaconazole (OS: USAN, BAN)
  • SCH 56592 (IS: ScheringPlough)

Brand Names

  • Noxafil
    Haemato Pharm, Austria; Merck Sharp & Dohme, Austria; Merck Sharp & Dohme, Australia; Merck Sharp & Dohme, Chile; Merck Sharp & Dohme, Colombia; Merck Sharp & Dohme, Czech Republic; Merck Sharp & Dohme, Spain; Merck Sharp & Dohme, United Kingdom; Merck Sharp & Dohme, Greece; Merck Sharp & Dohme, Hong Kong; Merck Sharp & Dohme, Croatia (Hrvatska); Merck Sharp & Dohme, Iceland; Merck Sharp & Dohme, Lithuania; Merck Sharp & Dohme, Malaysia; Merck Sharp & Dohme, New Zealand; Merck Sharp & Dohme, Philippines; Merck Sharp & Dohme, Portugal; Merck Sharp & Dohme, Romania; Merck Sharp & Dohme, Slovenia; Merck Sharp & Dohme, Slovakia; MSD, Switzerland; MSD, Costa Rica; MSD, Denmark; MSD, Dominican Republic; MSD, Finland; MSD, Guatemala; MSD, Honduras; MSD, Ireland; MSD, Nicaragua; MSD, Netherlands; MSD, Norway; MSD, Panama; MSD, Sweden; MSD, El Salvador; MSD, Thailand; MSD Belgium, Belgium; MSD France, France; MSD Merck Sharp & Dohme, Turkey; MSD Pharma, Hungary; MSD Polska, Poland; Patheon, China; Schering, United States; Schering-Plough, Georgia; Schering-Plough, Israel; Schering-Plough, Italy; Schering-Plough, Oman; Schering-Plough, Serbia; Schering-Plough, South Africa
  • NOXAFIL
    MSD SHARP & DOHME, Germany
  • Posaconazole SP
    Schering-Plough, Lithuania
  • Posanol
    Merck, Canada
  • Posatex (Posaconazole and Mometasone, + Orbifloxacin (veterinary use))
    Intervet, Belgium; Intervet, United Kingdom; Intervet, Italy; Intervet, Netherlands; Intervet, United States; Intervet International, Austria; MSD, Germany; MSD Animal, Norway; MSD Animal Health, Switzerland; Selecta, Germany; MSD Santé Animale Intervet, France

International Drug Name Search

Glossary

TermDefinition
BANBritish Approved Name
IUPACInternational Union of Pure and Applied Chemistry
ISInofficial Synonym
OSOfficial Synonym
Rec.INNRecommended International Nonproprietary Name (World Health Organization)
USANUnited States Adopted Name
WHOWorld Health Organization

Click for further information on drug naming conventions and International Nonproprietary Names.

Important Notice: The Drugs.com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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