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In the US, Glucarpidase (glucarpidase systemic) is a member of the drug class antidotes and is used to treat Methotrexate Overdosage.

US matches:



ATC (Anatomical Therapeutic Chemical Classification)


CAS registry number (Chemical Abstracts Service)


Chemical Formula

C1950-H3157-N543-O599-S7 (monomer)

Therapeutic Categories

Detoxifying agent for antineoplastic treatment

Recombinant enzym

Chemical Name

Recombinant glutamate carboxypeptidase (carboxypeptidase G2) (WHO )

Foreign Names

  • Glucarpidaseum (Latin)
  • Glucarpidase (German)
  • Glucarpidase (French)
  • Glucarpidasa (Spanish)

Generic Names

  • Acetylaspartylglutamate dipeptidase (IS)
  • Folylpolyglutamate hydrolase (IS)
  • Folylpoly-Ý-glutamate carboxypeptidase (IS)
  • Poly(Ý-glutamic acid) endohydrolase (IS)
  • Pteroylpolyglutamic acid hydrolase (IS)

Brand Names

  • Voraxaze
    BTG, United States; BTG International, Singapore


ISInofficial Synonym
Rec.INNRecommended International Nonproprietary Name (World Health Organization)

Further information on drug naming conventions: International Nonproprietary Names.

Important Notice: The international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.